Spread of HTLV-I between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton

Cell contact is required for efficient transmission of human T cell leukemia virustype 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not u...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-03, Vol.299 (5613), p.1713-1716
Hauptverfasser:	Igakura, Tadahiko, Stinchcombe, Jane C., Peter K. C. Goon, Taylor, Graham P., Weber, Jonathan N., Griffiths, Gillian M., Tanaka, Yuetsu, Osame, Mitsuhiro, Charles R. M. Bangham
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult T-cell leukemia-lymphoma B lymphocytes Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - ultrastructure CD4-Positive T-Lymphocytes - virology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - ultrastructure CD8-Positive T-Lymphocytes - virology Cell Adhesion Molecules - metabolism Cell Communication Cell Line Cell Polarity Cellular receptors Company growth Enzymes Extracellular Space - virology Fundamental and applied biological sciences. Psychology Gene Products, env - metabolism Gene Products, gag - metabolism Genome, Viral Genomes Growth HIV HTLV-I (Virus) HTLV-I Infections - virology Human immunodeficiency virus Human T lymphotropic virus 1 Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - physiology Humans In Situ Hybridization, Fluorescence Intercellular junctions Intercellular Junctions - physiology Intercellular Junctions - ultrastructure Intercellular Junctions - virology Leukemia Lymphocytes Microbiology Microscopy, Confocal Microtubule organizing center Microtubule-Organizing Center - physiology Microtubule-Organizing Center - ultrastructure Microtubules - physiology Nucleocapsid Proteins - metabolism Peptide Nucleic Acids Physiology Receptors, Antigen, T-Cell - immunology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - ultrastructure T-Lymphocytes - virology Talin - metabolism Transmission efficiency Virion - physiology Virology Viruses
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