Specialized Inhibitory Synaptic Actions between Nearby Neocortical Pyramidal Neurons

We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal (excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-05, Vol.316 (5825), p.758-761
Hauptverfasser:	Ren, Ming, Yoshimura, Yumiko, Takada, Naoki, Horibe, Shoko, Komatsu, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Axons - metabolism Biological and medical sciences Cellular biology Electric Stimulation Excitatory Postsynaptic Potentials Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Glutamic Acid - pharmacology Inhibitor drugs Inhibitory Postsynaptic Potentials Interneurons Interneurons - physiology Kainic acid receptors Mice Mice, Inbred C57BL Nerves Neural Inhibition Neurons Neuroscience Neurotransmitters Patch-Clamp Techniques Presynaptic Terminals - physiology Pyramidal cells Pyramidal Cells - physiology Receptors Receptors, AMPA - physiology Receptors, Kainic Acid - physiology Rodents Signals Synapses Synapses - physiology Synaptic Transmission Vertebrates: nervous system and sense organs Visual Cortex - cytology Visual Cortex - physiology
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