Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the huntingtin protein. Transcriptional dysregulation has been implicated in HD pathogenesis. Here, we report that huntingtin interacts with the transcriptional activator Sp1 and...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-06, Vol.296 (5576), p.2238-2243
Hauptverfasser:	Dunah, Anthone W., Jeong, Hyunkyung, Griffin, April, Kim, Yong-Man, Standaert, David G., Hersch, Steven M., Mouradian, M. Maral, Young, Anne B., Tanese, Naoko, Krainc, Dimitri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Brain - metabolism Caudate nucleus Caudate Nucleus - metabolism Cell Death Cell Line Cell Nucleus - metabolism Cells, Cultured Corpus Striatum - cytology Corpus Striatum - embryology Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease DNA DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Down-Regulation Gene Expression Regulation Genes Genetic aspects Grade 1 Grade 4 Hippocampus Humans Huntingtin Protein Huntington Disease - genetics Huntington Disease - metabolism Huntington's chorea Huntington's disease Medical sciences Mice Mice, Transgenic Mutation Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurology Neurons Neurons - physiology Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleoproteins Patients Peptides Promoter Regions, Genetic Proteins Rats Receptors, Dopamine D2 - genetics Social interaction Solubility Sp1 Transcription Factor - chemistry Sp1 Transcription Factor - metabolism TATA-Binding Protein Associated Factors Transcription Factor TFIID Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic Transfection Transgenic animals Trinucleotide Repeat Expansion Two-Hybrid System Techniques
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