Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1

Timely deactivation of the α-subunit of the rod G-protein transducin (Gαt) is essential for the temporal resolution of rod vision. Regulators of G-protein signalling (RGS) proteins accelerate hydrolysis of GTP by the α-subunits of heterotrimeric G proteins in vitro. Several retinal RGS proteins can...

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Veröffentlicht in:	Nature (London) 2000-02, Vol.403 (6769), p.557-560
Hauptverfasser:	Simon, Melvin I, Chen, Ching-Kang, Burns, Marie E, He, Wei, Wensel, Theodore G, Baylor, Denis A
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - metabolism Animals Biological and medical sciences Cell physiology Cyclic Nucleotide Phosphodiesterases, Type 6 Eyes & eyesight Fundamental and applied biological sciences. Psychology G^b5-L protein GTP GTP Phosphohydrolases - metabolism GTPase accelerating protein Guanosine Triphosphate - metabolism Humanities and Social Sciences Hydrolysis letter Membranes Mice Mice, Inbred Strains Mice, Knockout Mice, Transgenic Molecular and cellular biology multidisciplinary Proteins Retinal Rod Photoreceptor Cells - metabolism RGS Proteins - genetics RGS Proteins - physiology RGS9-1 protein Rod Cell Outer Segment - metabolism Science Science (multidisciplinary) Space life sciences Transducin - metabolism Vision, Ocular - physiology Vision, photoreception
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