EFFECT OF SINGLE EXPOSURE TO TOLUENE ON SIDMAN AVOIDANCE RESPONSE IN RATS
Effects of single exposure to toluene on Sidman avoidance response in rats were studied. The animals, in which the behavioral base line had been established, were exposed 0, 1, 000 and 3, 000ppm of toluene vapor for 4 hours and the effects on the behavioral pattern were investigated using Sidman avo...
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| Veröffentlicht in: | Journal of toxicological sciences 1978/11/15, Vol.3(4), pp.305-312 |
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| container_title | Journal of toxicological sciences |
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| creator | SHIGETA, Sadayoshi AIKAWA, Hiroyuki MISAWA, Tetsuo KONDO, Atsuko |
| description | Effects of single exposure to toluene on Sidman avoidance response in rats were studied. The animals, in which the behavioral base line had been established, were exposed 0, 1, 000 and 3, 000ppm of toluene vapor for 4 hours and the effects on the behavioral pattern were investigated using Sidman avoidance test for one hour after the termination of toluene exposure. 1) Exposure to 0 or 1, 000 ppm of toluene did not produce marked change on the operant behavior. After the exposure to 3, 000 ppm, the animals produced increased responses with shortening of the inter-response-time (IRT) and no changes in shock counts from the beginning to the 50min. zone of the Sidman avoidance test when compared with those before exposure. The behavioral change indicated here appears to be caused by a temporary breakdown of the established timing of lever pressing. 2) The effect of toluene on the operant behavior was strongest immediately after the termination of the exposure and the behavior recovered in about an hour. This result suggested that toluene is rapidly transfered to and removed from the brain. |
| doi_str_mv | 10.2131/jts.3.305 |
| format | Article |
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The animals, in which the behavioral base line had been established, were exposed 0, 1, 000 and 3, 000ppm of toluene vapor for 4 hours and the effects on the behavioral pattern were investigated using Sidman avoidance test for one hour after the termination of toluene exposure. 1) Exposure to 0 or 1, 000 ppm of toluene did not produce marked change on the operant behavior. After the exposure to 3, 000 ppm, the animals produced increased responses with shortening of the inter-response-time (IRT) and no changes in shock counts from the beginning to the 50min. zone of the Sidman avoidance test when compared with those before exposure. The behavioral change indicated here appears to be caused by a temporary breakdown of the established timing of lever pressing. 2) The effect of toluene on the operant behavior was strongest immediately after the termination of the exposure and the behavior recovered in about an hour. 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The animals, in which the behavioral base line had been established, were exposed 0, 1, 000 and 3, 000ppm of toluene vapor for 4 hours and the effects on the behavioral pattern were investigated using Sidman avoidance test for one hour after the termination of toluene exposure. 1) Exposure to 0 or 1, 000 ppm of toluene did not produce marked change on the operant behavior. After the exposure to 3, 000 ppm, the animals produced increased responses with shortening of the inter-response-time (IRT) and no changes in shock counts from the beginning to the 50min. zone of the Sidman avoidance test when compared with those before exposure. The behavioral change indicated here appears to be caused by a temporary breakdown of the established timing of lever pressing. 2) The effect of toluene on the operant behavior was strongest immediately after the termination of the exposure and the behavior recovered in about an hour. This result suggested that toluene is rapidly transfered to and removed from the brain.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Conditioning, Operant - drug effects</subject><subject>Male</subject><subject>Organic Solvent</subject><subject>Rats</subject><subject>Time Factors</subject><subject>Toluene - pharmacology</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM9r2zAUx0XZumXpDrvvICgUdnD65CfL1tEkSmpI7RC7YzehKPKWkB-tlRz630_FJYfCe7zD58OXx5eQHwxGMUN2vz35EY4QkisyYFkGEcpMfiIDwCyLGCbwlXzzfgsQp5DwL-Q6RZmIdEAKNZ2qcUOrKa2LcjZXVP1ZVPXTUtGmCjN_UqWiVRno5DEvaf67KiZ5OVZ0qepFVdaKFiVd5k19Qz63Zufd9_c7JM1UNeOHaF7NinE-jyzHLIkcrq0RgrXCggAQglsHLaI0rk0QQVgm3Uq2hosVWwNjsWPC8liyWEqwOCR3fexzd3w5O3_S-423brczB3c8e51y5JwDD-LtB3F7PHeH8JpmXGRpzCGGYP3qLdsdve9cq5-7zd50r5qBfqtWh2o16lBtcH--J55Xe7e-mH2XAec93vqT-esu2HSnjd25tyAmUxHCeL-QXJj9ZzrtDvgf5HaChA</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>SHIGETA, Sadayoshi</creator><creator>AIKAWA, Hiroyuki</creator><creator>MISAWA, Tetsuo</creator><creator>KONDO, Atsuko</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>1978</creationdate><title>EFFECT OF SINGLE EXPOSURE TO TOLUENE ON SIDMAN AVOIDANCE RESPONSE IN RATS</title><author>SHIGETA, Sadayoshi ; AIKAWA, Hiroyuki ; MISAWA, Tetsuo ; KONDO, Atsuko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4385-e3dca661f6c0600664ce0f339aef53306c19eb9fa46b1d0112e16c42912990c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Conditioning, Operant - drug effects</topic><topic>Male</topic><topic>Organic Solvent</topic><topic>Rats</topic><topic>Time Factors</topic><topic>Toluene - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIGETA, Sadayoshi</creatorcontrib><creatorcontrib>AIKAWA, Hiroyuki</creatorcontrib><creatorcontrib>MISAWA, Tetsuo</creatorcontrib><creatorcontrib>KONDO, Atsuko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIGETA, Sadayoshi</au><au>AIKAWA, Hiroyuki</au><au>MISAWA, Tetsuo</au><au>KONDO, Atsuko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF SINGLE EXPOSURE TO TOLUENE ON SIDMAN AVOIDANCE RESPONSE IN RATS</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>1978</date><risdate>1978</risdate><volume>3</volume><issue>4</issue><spage>305</spage><epage>312</epage><pages>305-312</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>Effects of single exposure to toluene on Sidman avoidance response in rats were studied. The animals, in which the behavioral base line had been established, were exposed 0, 1, 000 and 3, 000ppm of toluene vapor for 4 hours and the effects on the behavioral pattern were investigated using Sidman avoidance test for one hour after the termination of toluene exposure. 1) Exposure to 0 or 1, 000 ppm of toluene did not produce marked change on the operant behavior. After the exposure to 3, 000 ppm, the animals produced increased responses with shortening of the inter-response-time (IRT) and no changes in shock counts from the beginning to the 50min. zone of the Sidman avoidance test when compared with those before exposure. The behavioral change indicated here appears to be caused by a temporary breakdown of the established timing of lever pressing. 2) The effect of toluene on the operant behavior was strongest immediately after the termination of the exposure and the behavior recovered in about an hour. 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| ispartof | The Journal of Toxicological Sciences, 1978/11/15, Vol.3(4), pp.305-312 |
| issn | 0388-1350 1880-3989 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Avoidance Learning - drug effects Conditioning, Operant - drug effects Male Organic Solvent Rats Time Factors Toluene - pharmacology |
| title | EFFECT OF SINGLE EXPOSURE TO TOLUENE ON SIDMAN AVOIDANCE RESPONSE IN RATS |
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