Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness
Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effe...
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| Veröffentlicht in: | Toxicology and industrial health 2001-06, Vol.17 (5-10), p.294-297 |
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| creator | Henderson, Rogene F Barr, Edward B Blackwell, Walter B Clark, Connie R Conn, Carole A Kalra, Roma March, Thomas H Sopori, Mohan L Tesfaigzi, Yohannes Ménache, Margaret G Mash, Deborah C Dokladny, Karol Kozak, Wieslaw Kozak, Anna Wachulec, Maceij Rudolph, Karin Kluger, Matthew J Singh, Shashi P Razani-Boroujerdi, Seddigheh Langley, Raymond J |
| description | Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas. |
| doi_str_mv | 10.1191/0748233701th105oa |
| format | Article |
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The exposures also depressed the immune system. 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The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>12539875</pmid><doi>10.1191/0748233701th105oa</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0748-2337 |
| ispartof | Toxicology and industrial health, 2001-06, Vol.17 (5-10), p.294-297 |
| issn | 0748-2337 1477-0393 |
| language | eng |
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| source | Access via SAGE; MEDLINE |
| subjects | Animals Autoradiography Blood Body temperature Brain - drug effects Brain - pathology Brain research Chemical Warfare Agents - adverse effects Cognition Disorders - etiology Disease Models, Animal Heat Immune System - drug effects Inhalation Exposure Memory Memory Disorders - etiology Persian Gulf Syndrome Persian Gulf War Rats Rats, Inbred F344 Receptors, Cholinergic - analysis Receptors, Cholinergic - drug effects Sarin - adverse effects Spleen Toxicology |
| title | Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness |
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