Requirement of ERK Activation for Visual Cortical Plasticity
Experience-dependent plasticity in the developing visual cortex depends on electrical activity and molecular signals involved in stabilization or removal of inputs. Extracellular signal-regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated b...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2001-06, Vol.292 (5525), p.2337-2340 |
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| creator | di Cristo, Graziella Berardi, Nicoletta Cancedda, Laura Pizzorusso, Tommaso Putignano, Elena Ratto, Gian Michele Maffei, Lamberto |
| description | Experience-dependent plasticity in the developing visual cortex depends on electrical activity and molecular signals involved in stabilization or removal of inputs. Extracellular signal-regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated by both factors. We show that two different inhibitors of the ERK pathway suppress the induction of two forms of long-term potentiation (LTP) in rat cortical slices and that their intracortical administration to monocularly deprived rats prevents the shift in ocular dominance towards the nondeprived eye. These results demonstrate that the ERK pathway is necessary for experience-dependent plasticity and for LTP of synaptic transmission in the developing visual cortex. |
| doi_str_mv | 10.1126/science.1059075 |
| format | Article |
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These results demonstrate that the ERK pathway is necessary for experience-dependent plasticity and for LTP of synaptic transmission in the developing visual cortex.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1059075</identifier><identifier>PMID: 11423664</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Biological and medical sciences ; Brain ; Butadienes - pharmacology ; Electric potential ; Enzyme Activation ; Enzyme Inhibitors - pharmacology ; Evoked Potentials, Visual - drug effects ; extracellular signal-regulated kinase ; Eye and associated structures. Visual pathways and centers. Vision ; Eyes ; Eyes & eyesight ; Flavonoids - pharmacology ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Inhibition ; Logical Thinking ; Long term potentiation ; Long-Term Potentiation - drug effects ; MAP Kinase Signaling System - drug effects ; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinases - antagonists & inhibitors ; Mitogen-Activated Protein Kinases - metabolism ; Molecules ; Neurochemistry ; Neurology ; Neurons ; Neuroscience ; Nitriles - pharmacology ; Ocular dominance ; Phosphorylation ; Photic Stimulation ; Proteins ; Rats ; Rodents ; Sensors ; Vehicles ; Vertebrates: nervous system and sense organs ; Vision, Ocular - drug effects ; Visual cortex ; Visual Cortex - drug effects ; Visual Cortex - physiology ; Visual Perception - drug effects</subject><ispartof>Science (American Association for the Advancement of Science), 2001-06, Vol.292 (5525), p.2337-2340</ispartof><rights>Copyright 2001 American Association for the Advancement of Science</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jun 22, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c774t-da39f46b0fa8a9fca6bc7668d43a8060aac895bd5e34f840e5bca909472c42233</citedby><cites>FETCH-LOGICAL-c774t-da39f46b0fa8a9fca6bc7668d43a8060aac895bd5e34f840e5bca909472c42233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3083890$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3083890$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1064727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11423664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>di Cristo, Graziella</creatorcontrib><creatorcontrib>Berardi, Nicoletta</creatorcontrib><creatorcontrib>Cancedda, Laura</creatorcontrib><creatorcontrib>Pizzorusso, Tommaso</creatorcontrib><creatorcontrib>Putignano, Elena</creatorcontrib><creatorcontrib>Ratto, Gian Michele</creatorcontrib><creatorcontrib>Maffei, Lamberto</creatorcontrib><title>Requirement of ERK Activation for Visual Cortical Plasticity</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Experience-dependent plasticity in the developing visual cortex depends on electrical activity and molecular signals involved in stabilization or removal of inputs. Extracellular signal-regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated by both factors. We show that two different inhibitors of the ERK pathway suppress the induction of two forms of long-term potentiation (LTP) in rat cortical slices and that their intracortical administration to monocularly deprived rats prevents the shift in ocular dominance towards the nondeprived eye. These results demonstrate that the ERK pathway is necessary for experience-dependent plasticity and for LTP of synaptic transmission in the developing visual cortex.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Butadienes - pharmacology</subject><subject>Electric potential</subject><subject>Enzyme Activation</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Evoked Potentials, Visual - drug effects</subject><subject>extracellular signal-regulated kinase</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eyes</subject><subject>Eyes & eyesight</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. 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Visual pathways and centers. Vision</topic><topic>Eyes</topic><topic>Eyes & eyesight</topic><topic>Flavonoids - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Inhibition</topic><topic>Logical Thinking</topic><topic>Long term potentiation</topic><topic>Long-Term Potentiation - drug effects</topic><topic>MAP Kinase Signaling System - drug effects</topic><topic>Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3</topic><topic>Mitogen-Activated Protein Kinases - antagonists & inhibitors</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Molecules</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neuroscience</topic><topic>Nitriles - pharmacology</topic><topic>Ocular dominance</topic><topic>Phosphorylation</topic><topic>Photic Stimulation</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sensors</topic><topic>Vehicles</topic><topic>Vertebrates: nervous system and sense 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Extracellular signal-regulated kinase 1,2 (also called p42/44 mitogen-activated protein kinase) activation in the cortex is regulated by both factors. We show that two different inhibitors of the ERK pathway suppress the induction of two forms of long-term potentiation (LTP) in rat cortical slices and that their intracortical administration to monocularly deprived rats prevents the shift in ocular dominance towards the nondeprived eye. These results demonstrate that the ERK pathway is necessary for experience-dependent plasticity and for LTP of synaptic transmission in the developing visual cortex.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>11423664</pmid><doi>10.1126/science.1059075</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2001-06, Vol.292 (5525), p.2337-2340 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743423578 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Biological and medical sciences Brain Butadienes - pharmacology Electric potential Enzyme Activation Enzyme Inhibitors - pharmacology Evoked Potentials, Visual - drug effects extracellular signal-regulated kinase Eye and associated structures. Visual pathways and centers. Vision Eyes Eyes & eyesight Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Inhibition Logical Thinking Long term potentiation Long-Term Potentiation - drug effects MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Molecules Neurochemistry Neurology Neurons Neuroscience Nitriles - pharmacology Ocular dominance Phosphorylation Photic Stimulation Proteins Rats Rodents Sensors Vehicles Vertebrates: nervous system and sense organs Vision, Ocular - drug effects Visual cortex Visual Cortex - drug effects Visual Cortex - physiology Visual Perception - drug effects |
| title | Requirement of ERK Activation for Visual Cortical Plasticity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A34%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Requirement%20of%20ERK%20Activation%20for%20Visual%20Cortical%20Plasticity&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=di%20Cristo,%20Graziella&rft.date=2001-06-22&rft.volume=292&rft.issue=5525&rft.spage=2337&rft.epage=2340&rft.pages=2337-2340&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1059075&rft_dat=%3Cgale_proqu%3EA76550919%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213571646&rft_id=info:pmid/11423664&rft_galeid=A76550919&rft_jstor_id=3083890&rfr_iscdi=true |