Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome

Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balance between stem cell self-renewal and differentiation is poorly understood. Here, we show that dividing Dr...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-09, Vol.301 (5639), p.1547-1550
Hauptverfasser:	Yamashita, Yukiko M., Jones, D. Leanne, Fuller, Margaret T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabidopsis Proteins beta Catenin Biological and medical sciences Cadherins - metabolism Calcium-Binding Proteins - metabolism Cell Count Cell cycle Cell cycle, cell proliferation Cell Differentiation Cell Division Cell physiology Cell Polarity Centrosome - physiology Centrosomes Cytoskeletal Proteins - metabolism Daughter cells Daughters Double stranded RNA Drosophila Drosophila - cytology Drosophila - genetics Drosophila - physiology Drosophila Proteins - metabolism Fundamental and applied biological sciences. Psychology Germ cells Germ Cells - cytology Germ Cells - physiology Homeodomain Proteins - genetics Homeodomain Proteins - physiology Individualized Instruction Male Male animals Males Mitotic spindle apparatus Molecular and cellular biology Mutation Physiological aspects Proteins Spindle Apparatus - physiology Stem cells Stem Cells - cytology Stem Cells - physiology Testes Testis - cytology Trans-Activators - metabolism Tubulin - metabolism Tumor Suppressor Proteins - metabolism Tumors
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