RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension

The RNA world hypothesis regarding the early evolution of life relies on the premise that some RNA sequences can catalyze RNA replication. In support of this conjecture, we describe here an RNA molecule that catalyzes the type of polymerization needed for RNA replication. The ribozyme uses nucleosid...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-05, Vol.292 (5520), p.1319-1325
Hauptverfasser:	Johnston, Wendy K., Unrau, Peter J., Lawrence, Michael S., Glasner, Margaret E., Bartel, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Art and archaeology Base Sequence Coding Conserved Sequence - genetics Directed Molecular Evolution DNA Evolution Family (Sociological Unit) Gels Hypotheses Molecular Sequence Data Molecules Mutagenesis Mutagenesis - genetics Nucleic Acid Conformation Nucleotide sequences Nucleotides Oligonucleotides Polymerase chain reaction Polymerization Polymers Research Article Ribonucleic acid RNA RNA - biosynthesis RNA - genetics RNA polymerases RNA Replicase - chemistry RNA Replicase - genetics RNA Replicase - metabolism RNA, Catalytic - chemistry RNA, Catalytic - genetics RNA, Catalytic - metabolism Sequence Analysis, RNA Substrate Specificity Templates, Genetic
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