Role of Anthocyanidin Reductase, Encoded by BANYULS in Plant Flavonoid Biosynthesis

Condensed tannins (CTs) are flavonoid oligomers, many of which have beneficial effects on animal and human health. The flavanol (-)-epicatechin is a component of many CTs and contributes to flavor and astringency in tea and wine. We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Med...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-01, Vol.299 (5605), p.396-399
Hauptverfasser:	Xie, De-Yu, Sharma, Shashi B., Paiva, Nancy L., Ferreira, Daneel, Dixon, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anthocyanin Anthocyanins Anthocyanins - biosynthesis Anthocyanins - chemistry Anthocyanins - metabolism Arabidopsis - enzymology Arabidopsis - genetics Arabidopsis Proteins Bioflavonoids Biological and medical sciences Biosynthesis Botany Catechin - metabolism Circular Dichroism Enzymes Flavones Flavonoids Flowers & plants Fundamental and applied biological sciences. Psychology Genes Genes, Plant Leaves Magnetic Resonance Spectroscopy Medicago - enzymology Medicago - genetics Metabolism Metabolism. Physicochemical requirements Molecular Sequence Data NAD - metabolism NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADP - metabolism Nicotiana - genetics Nutritional aspects Oxidation-Reduction Oxygenases - metabolism Petals Plant cells Plant physiology and development Plants Plants, Genetically Modified Proanthocyanidins Recombinant Proteins - metabolism Scientific Concepts Seeds - metabolism Stereoisomerism Tannins Tannins - biosynthesis Tannins - chemistry Testa Transgenic plants
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Beschreibung
Zusammenfassung:	Condensed tannins (CTs) are flavonoid oligomers, many of which have beneficial effects on animal and human health. The flavanol (-)-epicatechin is a component of many CTs and contributes to flavor and astringency in tea and wine. We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Medicago truncatula encode anthocyanidin reductase, which converts anthocyanidins to their corresponding 2,3-cis-flavan-3-ols. Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1078540