Role of GTP Hydrolysis in Fission of Caveolae Directly from Plasma Membranes

Caveolae are specialized invaginated cell surface microdomains of undefined function. A cell-free system that reconstituted fission of caveolae from lung endothelial plasma membranes was developed. Addition of cytosol and the hydrolysis of guanosine triphosphate (GTP) induced caveolar fission. The b...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-10, Vol.274 (5285), p.239-242
Hauptverfasser:	Schnitzer, Jan E., Oh, Phil, McIntosh, Deirdre P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Budding Cattle Caveolae Caveolin 1 Caveolins Cell Membrane - chemistry Cell Membrane - metabolism Cell Membrane - ultrastructure Cell membranes Cell physiology Cell-Free System Cellular biology Centrifugation, Density Gradient Cholera Toxin - metabolism Cytosol Endocytosis Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fractions Fundamental and applied biological sciences. Psychology GTPases Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine triphosphatase Guanosine Triphosphate - metabolism Guanosine Triphosphate - pharmacology Hydrolysis Lungs Membrane and intracellular transports Membrane Proteins - analysis Membrane Proteins - metabolism Membranes Molecular and cellular biology P branes Proteins Rats
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