Role for the p53 homologue p73 in E2F-1-induced apoptosis

The transcription factor E2F-1 induces both cell-cycle progression and, in certain settings, apoptosis. E2F-1 uses both p53-dependent and p53-independent pathways to kill cells 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 . The p53-dependent pathway involves the induction by E2F-1 of the human tumour-suppressor pr...

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Veröffentlicht in:	Nature (London) 2000-10, Vol.407 (6804), p.645-648
Hauptverfasser:	Irwin, Meredith, Marin, Maria Carmen, Phillips, Andrew C., Seelan, Ratnam S., Smith, David I., Liu, Wanguo, Flores, Elsa R., Tsai, Kenneth Y., Jacks, Tyler, Vousden, Karen H., Kaelin Jr, William G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis Biochemistry Biological and medical sciences Carrier Proteins Cell Cycle Proteins Cell Line Cell physiology Cellular biology DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology E2F Transcription Factors E2F-1 protein E2F1 Transcription Factor Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, Tumor Suppressor Humanities and Social Sciences letter Mice Molecular and cellular biology multidisciplinary Mutation Nuclear Proteins - genetics Nuclear Proteins - physiology p53 gene p73 gene Protein Binding Proteins Retinoblastoma-Binding Protein 1 Science Science (multidisciplinary) Transcription Factor DP1 Transcription Factors - physiology Transcription, Genetic Tumor Protein p73 Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Proteins
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