Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle

The mechanisms that determine how folding attempts are interrupted to target folding-incompetent proteins for endoplasmic reticulum-associated degradation (ERAD) are poorly defined. Here the α-mannosidase I-like protein EDEM was shown to extract misfolded glycoproteins, but not glycoproteins under-g...

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