Regulation of STAT3 by Direct Binding to the Rac1 GTPase

The signal transducers and activators of transcription (STAT) transcription factors become phosphorylated on tyrosine and translocate to the nucleus after stimulation of cells with growth factors or cytokines. We show that the Rac1 guanosine triphosphatase can bind to and regulate STAT3 activity. Do...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2000-10, Vol.290 (5489), p.144-147
Hauptverfasser:	Simon, Amy R., Vikis, Haris G., Stewart, Scott, Fanburg, Barry L., Cochran, Brent H., Guan, Kun-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Antibodies Biological and medical sciences Cell Line Cell physiology Cellular biology Cercopithecus aethiops Chemical bonds Coding Complementary DNA COS Cells DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Activation Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, Reporter Genetic transcription Genetic Vectors Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism HeLa cells Humans Janus Kinase 2 Molecular and cellular biology Molecules Mutation Neoplasm Proteins Neurons Phosphorus Phosphorylation Phosphoserine - metabolism Phosphotyrosine - metabolism Plant cells Plasmids Protein-Tyrosine Kinases - metabolism Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rac1 protein Rats Signal Transduction STAT3 Transcription Factor T-Lymphoma Invasion and Metastasis-inducing Protein 1 Trans-Activators - genetics Trans-Activators - metabolism Transcription (Genetics) Transfection Two-Hybrid System Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!