Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

Expression of multiple oncogenes and inactivation of tumour suppressors is required to transform primary mammalian cells into cancer cells 1 , 2 , 3 . Activated Ha- RasV12 (Ras) is usually associated with cancer, but it also produces paradoxical premature senescence 4 in primary cells by inducing re...

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Veröffentlicht in:	Nature (London) 2004-12, Vol.432 (7017), p.640-645
Hauptverfasser:	Wu, Chaowei, Miloslavskaya, Irene, Demontis, Silvia, Maestro, Roberta, Galaktionov, Konstantin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino Acid Sequence Animals Biological and medical sciences Cancer Cell Line Cell Transformation, Neoplastic Cells Cellular Senescence Fibroblasts Gene expression Humanities and Social Sciences Humans Inactivation letter Medical sciences Molecular Sequence Data multidisciplinary Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - metabolism Oncogene Protein p21(ras) - genetics Oncogene Protein p21(ras) - metabolism Oncology Other treatments Oxidative Stress Oxidoreductases Acting on CH-CH Group Donors - chemistry Oxidoreductases Acting on CH-CH Group Donors - metabolism Protein Binding Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Rats Science Science (multidisciplinary) Treatment. General aspects Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - metabolism Tumors
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