Recombination Multiply infected spleen cells in HIV patients
The genome of the human immunodeficiency virus is highly prone to recombination, although it is not obvious whether recombinants arise infrequently or whether they are constantly being spawned but escape identification because of the massive and rapid turnover of virus particles. Here we use fluores...
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| Veröffentlicht in: | Nature (London) 2002-07, Vol.418 (6894), p.144-144 |
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| creator | Meyerhans, Andreas Jung, Andreas Maier, Reinhard Vartanian, Jean-Pierre Bocharov, Gennady Jung, Volker Fischer, Ulrike Meese, Eckart Wain-Hobson, Simon |
| description | The genome of the human immunodeficiency virus is highly prone to recombination, although it is not obvious whether recombinants arise infrequently or whether they are constantly being spawned but escape identification because of the massive and rapid turnover of virus particles. Here we use fluorescence in situ hybridization to estimate the number of proviruses harboured by individual splenocytes from two HIV patients, and determine the extent of recombination by sequencing amplified DNA from these cells. We find an average of three or four proviruses per cell and evidence for huge numbers of recombinants and extensive genetic variation. Although this creates problems for phylogenetic analyses, which ignore recombination effects, the intracellular variation may help to broaden immune recognition. |
| doi_str_mv | 10.1038/418144a |
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Here we use fluorescence in situ hybridization to estimate the number of proviruses harboured by individual splenocytes from two HIV patients, and determine the extent of recombination by sequencing amplified DNA from these cells. We find an average of three or four proviruses per cell and evidence for huge numbers of recombinants and extensive genetic variation. Although this creates problems for phylogenetic analyses, which ignore recombination effects, the intracellular variation may help to broaden immune recognition.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/418144a</identifier><identifier>PMID: 12110879</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Amino Acid Sequence ; Deoxyribonucleic acid ; DNA ; Evolution, Molecular ; Fluorescence ; Gene Products, env - genetics ; Genetic diversity ; Genomes ; HIV ; HIV Infections - immunology ; HIV Infections - pathology ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - genetics ; HIV-1 - immunology ; HIV-1 - isolation & purification ; Human immunodeficiency virus ; Humans ; Hybridization ; In Situ Hybridization, Fluorescence ; Kinetics ; Molecular Sequence Data ; Patients ; Phylogenetics ; Phylogeny ; Polymerase chain reaction ; Proviruses - genetics ; Proviruses - isolation & purification ; Recombination, Genetic - genetics ; Spleen - immunology ; Spleen - virology ; Virology ; Viruses</subject><ispartof>Nature (London), 2002-07, Vol.418 (6894), p.144-144</ispartof><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 11, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12110879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyerhans, Andreas</creatorcontrib><creatorcontrib>Jung, Andreas</creatorcontrib><creatorcontrib>Maier, Reinhard</creatorcontrib><creatorcontrib>Vartanian, Jean-Pierre</creatorcontrib><creatorcontrib>Bocharov, Gennady</creatorcontrib><creatorcontrib>Jung, Volker</creatorcontrib><creatorcontrib>Fischer, Ulrike</creatorcontrib><creatorcontrib>Meese, Eckart</creatorcontrib><creatorcontrib>Wain-Hobson, Simon</creatorcontrib><title>Recombination Multiply infected spleen cells in HIV patients</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>The genome of the human immunodeficiency virus is highly prone to recombination, although it is not obvious whether recombinants arise infrequently or whether they are constantly being spawned but escape identification because of the massive and rapid turnover of virus particles. 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Here we use fluorescence in situ hybridization to estimate the number of proviruses harboured by individual splenocytes from two HIV patients, and determine the extent of recombination by sequencing amplified DNA from these cells. We find an average of three or four proviruses per cell and evidence for huge numbers of recombinants and extensive genetic variation. Although this creates problems for phylogenetic analyses, which ignore recombination effects, the intracellular variation may help to broaden immune recognition.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>12110879</pmid><doi>10.1038/418144a</doi><tpages>1</tpages></addata></record> |
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| subjects | Acquired immune deficiency syndrome AIDS Amino Acid Sequence Deoxyribonucleic acid DNA Evolution, Molecular Fluorescence Gene Products, env - genetics Genetic diversity Genomes HIV HIV Infections - immunology HIV Infections - pathology HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - immunology HIV-1 - isolation & purification Human immunodeficiency virus Humans Hybridization In Situ Hybridization, Fluorescence Kinetics Molecular Sequence Data Patients Phylogenetics Phylogeny Polymerase chain reaction Proviruses - genetics Proviruses - isolation & purification Recombination, Genetic - genetics Spleen - immunology Spleen - virology Virology Viruses |
| title | Recombination Multiply infected spleen cells in HIV patients |
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