Optimization of specificity in a cellular protein interaction network by negative selection

Most proteins that participate in cellular signalling networks contain modular protein-interaction domains. Multiple versions of such domains are present within a given organism: the yeast proteome, for example, contains 27 different Src homology 3 (SH3) domains. This raises the potential problem of...

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Veröffentlicht in:	Nature 2003-12, Vol.426 (6967), p.676-680
Hauptverfasser:	Lim, Wendell A, Zarrinpar, Ali, Park, Sang-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Binding, Competitive Biological and medical sciences cell signaling cell signalling Cellular biology Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Ligands Membrane Proteins - chemistry Membrane Proteins - metabolism Mitogen-Activated Protein Kinase Kinases - chemistry Mitogen-Activated Protein Kinase Kinases - metabolism Molecular biophysics Molecular Sequence Data Pbs2 protein Peptides Protein Binding protein interactions Proteins Proteome - chemistry Proteome - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Sho1 protein Species Specificity src Homology Domains Substrate Specificity Yeast Yeasts
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