Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

Steroid-thyroid hormone receptors typically bind as dimers to DNA sequences that contain repeated elements termed half-sites. NGFI-B, an early response protein and orphan member of this receptor superfamily, binds to a DNA sequence that contains only one half-site (5′-AAAGGTCA-3′). A domain separate...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-04, Vol.256 (5053), p.107-110
Hauptverfasser:	Wilson, Thomas E., Paulsen, Ragnhild E., Padgett, Kerstien A., Milbrandt, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Base Sequence Binding Sites Biological and medical sciences Biology Cell Nucleus - physiology Cell receptors Cell structures and functions Chimeras CHO Cells Cricetinae Deoxyribonucleic acid DNA DNA - metabolism DNA binding proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gels Hormone receptors Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Hormones Kinetics Libraries Mice Mobility Molecular and cellular biology Molecular Sequence Data Monomers Nuclear Receptor Subfamily 4, Group A, Member 1 Nucleotides Oligodeoxyribonucleotides - metabolism Oligonucleotides Orphans Polymerase Chain Reaction Receptors Receptors, Cell Surface - metabolism Receptors, Cytoplasmic and Nuclear Receptors, Steroid Recombinant Fusion Proteins - metabolism Sequence Homology, Nucleic Acid Substrate Specificity Transcription Factors - genetics Transcription Factors - metabolism Transfection Zinc Fingers - genetics
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