Production of [alpha]1,3-Galactosyltransferase--deficient pigs

The enzyme alpha1,3-galactosyltransferase (alpha1,3GT or GGTA1) synthesizes alpha1,3-galactose (alpha1,3Gal) epitopes (Galalpha1,3Galbeta1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation. Complete removal of alpha1,3Gal from pig organs is...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-01, Vol.299 (5605), p.411-414
Hauptverfasser:	Phelps, Carol J, Koike, Chihiro, Vaught, Todd D, Boone, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning Coding Enzymes Genetic aspects Genetic research Hogs Pregnancy Swine Transcripts (Written Records) Xenotransplantation
Online-Zugang:	Volltext
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