Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement

TRIGGERING of mast cells and basophils by immunoglobulin E (IgE) and antigen induces various biochemical signals, including tyrosine kinase activation 1,2 , which lead to cell degranulation and the release of mediators of the allergic reaction. The high-affinity receptor for IgE (FcσRI) responsible...

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Veröffentlicht in:	Nature (London) 1991-10, Vol.353 (6347), p.855-858
Hauptverfasser:	Paolini, Rossella, Jouvin, Marie-Hélène, Kinet, Jean-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, B-Lymphocyte - isolation & purification Antigens, Differentiation, B-Lymphocyte - metabolism Biochemistry Biological and medical sciences Cell Line Cell Membrane - immunology Cellular biology Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Fundamental immunology Humanities and Social Sciences Immunobiology Immunoglobulin E - metabolism letter Leukemia, Experimental Macromolecular Substances Molecular Weight multidisciplinary Myeloid cells: ontogeny, maturation, markers, receptors Phosphoproteins - isolation & purification Phosphorylation Polynuclears Protein-Tyrosine Kinases - metabolism Rats Receptors, Fc - isolation & purification Receptors, Fc - metabolism Receptors, IgE Science Science (multidisciplinary)
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