Pharmacological Modulation of Perceptual Learning and Associated Cortical Reorganization

The pharmacological basis of perceptual learning and associated cortical reorganizations remains elusive. We induced perceptual learning by Hebbian coactivation of the skin of the tip of the right index finger in humans. Under placebo, tactile two-point discrimination was improved on the coactivated...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-07, Vol.301 (5629), p.91-94
Hauptverfasser:	Dinse, Hubert R., Ragert, Patrick, Pleger, Burkhard, Schwenkreis, Peter, Tegenthoff, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphetamine - pharmacology Biological and medical sciences Brain Mapping Cognition & reasoning Correlation Discrimination Learning Discrimination Learning - drug effects Drug effects Electric Stimulation Evoked Potentials, Somatosensory - drug effects Excitatory Amino Acid Antagonists - pharmacology Female Fingers Fundamental and applied biological sciences. Psychology Goodness of Fit Hemispheres Humans Learning Processes Long-Term Potentiation - drug effects Male Memantine - pharmacology Middle Aged Molecular and cellular biology N methyl D aspartate receptors Neuronal Plasticity - drug effects Perception - drug effects Perceptual learning Perceptual localization Pharmacological research Pharmacology Pharmacology, Experimental Physiological aspects Placebos Psychometrics Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Sensory discrimination Sensory perception Somatosensory Cortex - drug effects Somatosensory Cortex - physiology Statistical Analysis Tactile discrimination Touch Touch - drug effects
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