Enzymatic activity and thermal stability of PEG-[alpha]-chymotrypsin conjugates

a-Chymotrypsin was chemically modified with methoxypoly(ethylene glycol) (PEG) of different molecular weights (700, 2,000, and 5,000 Da) and the amount of polymer attached to the enzyme was varied systematically from 1 to 9 PEG molecules per enzyme molecule. Upon PEG conjugation, enzyme catalytic tu...

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Veröffentlicht in:	Biotechnology letters 2009-06, Vol.31 (6), p.883-887
Hauptverfasser:	Rodriguez-Martinez, Jose A, Rivera-Rivera, Izarys, Sola, Ricardo J, Griebenow, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Enzymatic activity Enzymes Inactivation Molecular weight Polyethylene glycol Polymers Proteins
Online-Zugang:	Volltext
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