Antibody neutralization and escape by HIV-1

Neutralizing antibodies (Nab) are a principal component of an effective human immune response to many pathogens, yet their role in HIV-1 infection is unclear. To gain a better understanding of this role, we examined plasma from patients with acute HIV infection. Here we report the detection of autol...

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Veröffentlicht in:	Nature (London) 2003-03, Vol.422 (6929), p.307-312
Hauptverfasser:	XIPING WEI, DECKER, Julie M, KOMAROVA, Natalia L, NOWAK, Martin A, HAHN, Beatrice H, KWONG, Peter D, SHAW, George M, SHUYI WANG, HUXIONG HUI, KAPPES, John C, XIAOYUN WU, SALAZAR-GONZALEZ, Jesus F, SALAZAR, Maria G, KILBY, J. Michael, SAAG, Michael S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - immunology Antibody Specificity Biological and medical sciences CD4 Antigens - immunology Epitopes - chemistry Epitopes - genetics Epitopes - immunology Fundamental and applied biological sciences. Psychology Glycosylation HIV HIV Antibodies - immunology HIV Antigens - chemistry HIV Antigens - genetics HIV Antigens - immunology HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - immunology HIV Infections - immunology HIV Infections - virology HIV-1 - chemistry HIV-1 - genetics HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus Humans Immune response Immune Sera - immunology Immune system Immunology Microbiology Models, Biological Molecular Sequence Data Mutagenesis Neutralization Neutralization Tests Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Time Factors Virology
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