Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1991-08, Vol.253 (5020), p.665-669
Hauptverfasser:	Nishisho, Isamu, Nakamura, Yusuke, Miyoshi, Yasuo, Miki, Yoshio, Ando, Hiroshi, Horii, Akira, Koyama, Kumiko, Utsunomiya, Joji, Baba, Shozo, Hedge, Philip, Markham, Alex, Krush, Anne J., Petersen, Gloria, Hamilton, Stanley R., Nilbert, Mef C., Levy, Daniel B., Bryan, Tracy M., Preisinger, Antonette C., Smith, Kelly J., Su, Li-Kuo, Kinzler, Kenneth W., Vogelstein, Bert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - genetics Amino Acid Sequence APC genes Base Sequence Biological and medical sciences Cancer Cell lines Chromosome abnormalities Chromosome Mapping Chromosomes, Human, Pair 5 Codon - genetics Codons Colonic Neoplasms - genetics Colorectal cancer DNA DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Exons Familial polyposis Gastroenterology. Liver. Pancreas. Abdomen Genetic aspects Genetic Linkage Genetic mutation Genetic Variation Genetics Humans Medical research Medical sciences Molecular Sequence Data Mutation Oligonucleotide Probes Point mutation Polymerase chain reaction Polymerase Chain Reaction - methods Polyposis, Familial Rectal Neoplasms - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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