Induction of Type I Diabetes by Kilham's Rat Virus in Diabetes-Resistant BB/Wor Rats

Type I diabetes mellitus is an autoimmune disease resulting from the interaction of genetic and environmental factors. A virus that was identified serologically as Kilham's rat virus (KRV) was isolated from a spontaneously diabetic rat and reproducibly induced diabetes in naive diabetes-resista...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1991-11, Vol.254 (5034), p.1010-1013
Hauptverfasser:	Guberski, D. L., Thomas, V. A., Shek, W. R., Like, A. A., Handler, E. S., Rossini, A. A., Wallace, J. E., Welsh, R. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Laboratory Antibodies Autoimmune diseases Diabetes Diabetes complications Diabetes mellitus Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - microbiology Diabetes Mellitus, Type 1 - pathology Disease Outbreaks - veterinary Genes, MHC Class I Haplotypes Hepatocytes Immunity (Disease) Infections Islet cells Islets of Langerhans - immunology Islets of Langerhans - pathology Medical research Parvoviridae Infections - complications Parvoviridae Infections - pathology Parvoviridae Infections - veterinary Rats Rats, Inbred BB Rodents Spleen cells Type 1 diabetes mellitus Viruses
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