Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activa...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-12, Vol.298 (5600), p.1911-1912
Hauptverfasser:	Johnson, Gary L., Lapadat, Razvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy Animals Apoptosis Autoimmune diseases Biological and medical sciences Cell Division Cell growth Cell physiology Cells Cytokines Cytokines - metabolism Drug regulation Environment Enzyme Activation Enzymes Feedback (Response) Fundamental and applied biological sciences. Psychology Gene Expression Regulation General aspects Humans Inhibition MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System Medical research Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 10 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinases - metabolism Mitogens Molecular and cellular biology Neoplasms - enzymology Neoplasms - pathology p38 Mitogen-Activated Protein Kinases Phosphorylation Physiological aspects Protein kinases Protein-Tyrosine Kinases - metabolism Proteins Regulator genes Signal transduction Stimuli Transcription, Genetic Tumors Viewpoint
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