Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activa...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2002-12, Vol.298 (5600), p.1911-1912 |
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| container_end_page | 1912 |
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| container_issue | 5600 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 298 |
| creator | Johnson, Gary L. Lapadat, Razvan |
| description | Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity. |
| doi_str_mv | 10.1126/science.1072682 |
| format | Article |
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The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1072682</identifier><identifier>PMID: 12471242</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Anatomy ; Animals ; Apoptosis ; Autoimmune diseases ; Biological and medical sciences ; Cell Division ; Cell growth ; Cell physiology ; Cells ; Cytokines ; Cytokines - metabolism ; Drug regulation ; Environment ; Enzyme Activation ; Enzymes ; Feedback (Response) ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; General aspects ; Humans ; Inhibition ; MAP Kinase Kinase Kinases - metabolism ; MAP Kinase Signaling System ; Medical research ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 10 ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinase 8 ; Mitogen-Activated Protein Kinase 9 ; Mitogen-Activated Protein Kinases - metabolism ; Mitogens ; Molecular and cellular biology ; Neoplasms - enzymology ; Neoplasms - pathology ; p38 Mitogen-Activated Protein Kinases ; Phosphorylation ; Physiological aspects ; Protein kinases ; Protein-Tyrosine Kinases - metabolism ; Proteins ; Regulator genes ; Signal transduction ; Stimuli ; Transcription, Genetic ; Tumors ; Viewpoint</subject><ispartof>Science (American Association for the Advancement of Science), 2002-12, Vol.298 (5600), p.1911-1912</ispartof><rights>Copyright 2002 American Association for the Advancement of Science</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2002 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2002 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Dec 6, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c769t-b7cbc88a180eb9242d1c31c77162a236ff816f62847e879d4dd087713ed3a2ec3</citedby><cites>FETCH-LOGICAL-c769t-b7cbc88a180eb9242d1c31c77162a236ff816f62847e879d4dd087713ed3a2ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3833110$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3833110$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14414165$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12471242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Gary L.</creatorcontrib><creatorcontrib>Lapadat, Razvan</creatorcontrib><title>Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity.</description><subject>Anatomy</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Cell growth</subject><subject>Cell physiology</subject><subject>Cells</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Drug regulation</subject><subject>Environment</subject><subject>Enzyme Activation</subject><subject>Enzymes</subject><subject>Feedback (Response)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>General aspects</subject><subject>Humans</subject><subject>Inhibition</subject><subject>MAP Kinase Kinase Kinases - metabolism</subject><subject>MAP Kinase Signaling System</subject><subject>Medical research</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 10</subject><subject>Mitogen-Activated Protein Kinase 3</subject><subject>Mitogen-Activated Protein Kinase 8</subject><subject>Mitogen-Activated Protein Kinase 9</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Mitogens</subject><subject>Molecular and cellular biology</subject><subject>Neoplasms - enzymology</subject><subject>Neoplasms - pathology</subject><subject>p38 Mitogen-Activated Protein Kinases</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Protein kinases</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proteins</subject><subject>Regulator genes</subject><subject>Signal transduction</subject><subject>Stimuli</subject><subject>Transcription, Genetic</subject><subject>Tumors</subject><subject>Viewpoint</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0ltv0zAUAOAIgVgZPPOCUITE5aHZfKvtPHbVKGPdOnF9tFznpLhKk852gP57XBoxdapQZdmWfD7fT5I8x-gEY8JPvbFQGzjBSBAuyYOkh1E-yHKC6MOkhxDlmURicJQ88X6BUIzl9HFyhAkTsZJe8v3KhmYOdTY0wf7UAYr0xjUBbJ1e2lp7SG90-PFLr316BYX9C2br9PzTZT_9eB0bXRfpisp7s_zT5FGpKw_Puv44-fr-_MvoQzaZji9Gw0lmBM9DNhNmZqTUWCKY5fFEBTYUGyEwJ5pQXpYS85ITyQRIkResKJCMUQoF1QQMPU7ebtdduea2BR_U0noDVaVraFqvBKMUcUlFlG_-L4lgghEc4at7cNG0ro63UDHKkcBys1p_i-a6AmXrsglOm_iQ4HTV1FDaODzMB5INmBhEnu3hsRSwtGaff7fjIwnwO8x16726-Hx9MJ1-O5iejQ-lcjzZof191DRVBXNQ8btH0x1-uuXGNd47KNXK2aV2a4WR2iS16pJadUkdZ7zsPqSdLaG4810WR_C6A9obXZVO18b6O8cYZphvtn6xdQsfGvcvTiWlGCP6B555Ahw</recordid><startdate>20021206</startdate><enddate>20021206</enddate><creator>Johnson, Gary L.</creator><creator>Lapadat, Razvan</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20021206</creationdate><title>Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases</title><author>Johnson, Gary L. ; 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These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>12471242</pmid><doi>10.1126/science.1072682</doi><tpages>2</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2002-12, Vol.298 (5600), p.1911-1912 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Anatomy Animals Apoptosis Autoimmune diseases Biological and medical sciences Cell Division Cell growth Cell physiology Cells Cytokines Cytokines - metabolism Drug regulation Environment Enzyme Activation Enzymes Feedback (Response) Fundamental and applied biological sciences. Psychology Gene Expression Regulation General aspects Humans Inhibition MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System Medical research Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 10 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 Mitogen-Activated Protein Kinases - metabolism Mitogens Molecular and cellular biology Neoplasms - enzymology Neoplasms - pathology p38 Mitogen-Activated Protein Kinases Phosphorylation Physiological aspects Protein kinases Protein-Tyrosine Kinases - metabolism Proteins Regulator genes Signal transduction Stimuli Transcription, Genetic Tumors Viewpoint |
| title | Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases |
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