Improved serum stability and biophysical properties of siRNAs following chemical modifications

Small interfering RNAs (siRNAs) which mediate sequence-specific gene silencing through RNA interference have been harnessed for therapeutic applications. Here, we found combinations of modest 2'-ribose siRNA modifications that permit effective gene silencing and improve siRNA stability in human...

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Veröffentlicht in:	Biotechnology letters 2008-11, Vol.30 (11), p.1901-1908
Hauptverfasser:	Cho, Ik Sang, Kim, Jung, Lim, Do Hwan, Ahn, Hee-Chul, Kim, Hyunggee, Lee, Kang-Bong, Lee, Young Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied Microbiology Biochemistry Biological and medical sciences Biomedical and Life Sciences Biophysics Biotechnology Blotting, Western Circular Dichroism Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HeLa Cells Humans Life Sciences Microbiology Nucleic Acid Denaturation Original Research Paper Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid Ribose - chemistry RNA RNA Interference RNA, Small Interfering - blood RNA, Small Interfering - chemistry RNA, Small Interfering - genetics Serum - chemistry Temperature Thermodynamics Transfection
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