Molecular Analyses of Oral Polio Vaccine Samples
It has been suggested that the human immunodeficiency virus (HIV), and thus the acquired immunodeficiency syndrome (AIDS) it causes, was inadvertently introduced to humans by the use of an oral polio vaccine (OPV) during a vaccination campaign launched by the Wistar Institute, Philadelphia, PA, USA,...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2001-04, Vol.292 (5517), p.743-744 |
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| creator | Poinar, Hendrik Kuch, Melanie Pääbo, Svante |
| description | It has been suggested that the human immunodeficiency virus (HIV), and thus the acquired immunodeficiency syndrome (AIDS) it causes, was inadvertently introduced to humans by the use of an oral polio vaccine (OPV) during a vaccination campaign launched by the Wistar Institute, Philadelphia, PA, USA, in the Belgian Congo in 1958 and 1959. The "OPV/AIDS hypothesis" suggests that the OPV used in this campaign was produced in chimpanzee kidney epithelial cell cultures rather than in monkey kidney cell cultures, as stated by H. Koprowski and co-workers, who produced the OPV. If chimpanzee cells were indeed used, this would lend support to the OPV/AIDS hypothesis, since chimpanzees harbor a simian immunodeficiency virus, widely accepted to be the origin of HIV-1. We analyzed several early OPV pools and found no evidence for the presence of chimpanzee DNA; by contrast, monkey DNA is present. |
| doi_str_mv | 10.1126/science.1058463 |
| format | Article |
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The "OPV/AIDS hypothesis" suggests that the OPV used in this campaign was produced in chimpanzee kidney epithelial cell cultures rather than in monkey kidney cell cultures, as stated by H. Koprowski and co-workers, who produced the OPV. If chimpanzee cells were indeed used, this would lend support to the OPV/AIDS hypothesis, since chimpanzees harbor a simian immunodeficiency virus, widely accepted to be the origin of HIV-1. 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Psychology ; Health. Pharmaceutical industry ; Human immunodeficiency virus ; Humans ; Industrial applications and implications. Economical aspects ; Kidney - cytology ; Mitochondrial DNA ; Monkeys & apes ; Oral poliovirus vaccine ; Pan paniscus - genetics ; Pan troglodytes ; Pan troglodytes - genetics ; Poliomyelitis vaccine ; Poliovirus ; Poliovirus - growth & development ; Poliovirus Vaccine, Oral - chemistry ; Poliovirus vaccines ; Polymerase Chain Reaction ; Production of active biomolecules ; Ribosomal DNA ; Simian immunodeficiency virus ; Theory ; Vaccination ; Vaccines ; Vaccins ; Virus Cultivation</subject><ispartof>Science (American Association for the Advancement of Science), 2001-04, Vol.292 (5517), p.743-744</ispartof><rights>Copyright 2001 American Association for the Advancement of Science</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2001 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Apr 27, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c706t-76ba854ad73469d2142d3cc6a81988a64eac97207dc1acdf70e95aea280861483</citedby><cites>FETCH-LOGICAL-c706t-76ba854ad73469d2142d3cc6a81988a64eac97207dc1acdf70e95aea280861483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3083554$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3083554$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=954887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11326104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poinar, Hendrik</creatorcontrib><creatorcontrib>Kuch, Melanie</creatorcontrib><creatorcontrib>Pääbo, Svante</creatorcontrib><title>Molecular Analyses of Oral Polio Vaccine Samples</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>It has been suggested that the human immunodeficiency virus (HIV), and thus the acquired immunodeficiency syndrome (AIDS) it causes, was inadvertently introduced to humans by the use of an oral polio vaccine (OPV) during a vaccination campaign launched by the Wistar Institute, Philadelphia, PA, USA, in the Belgian Congo in 1958 and 1959. The "OPV/AIDS hypothesis" suggests that the OPV used in this campaign was produced in chimpanzee kidney epithelial cell cultures rather than in monkey kidney cell cultures, as stated by H. Koprowski and co-workers, who produced the OPV. If chimpanzee cells were indeed used, this would lend support to the OPV/AIDS hypothesis, since chimpanzees harbor a simian immunodeficiency virus, widely accepted to be the origin of HIV-1. We analyzed several early OPV pools and found no evidence for the presence of chimpanzee DNA; by contrast, monkey DNA is present.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome (AIDS)</subject><subject>AIDS</subject><subject>AIDS (Disease)</subject><subject>AIDS research</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Causes and theories of causation</subject><subject>Cell Culture Techniques</subject><subject>Cells, Cultured</subject><subject>Cercopithecidae - genetics</subject><subject>Chimpanzees</subject><subject>Cultured cells</subject><subject>Diseases</subject><subject>DNA</subject><subject>DNA - analysis</subject><subject>DNA - genetics</subject><subject>DNA, Mitochondrial - analysis</subject><subject>DNA, Mitochondrial - genetics</subject><subject>DNA, Ribosomal - analysis</subject><subject>DNA, Ribosomal - genetics</subject><subject>Drug Contamination</subject><subject>Epithelial Cells</subject><subject>Etiology (Medicine)</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health. Pharmaceutical industry</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Kidney - cytology</subject><subject>Mitochondrial DNA</subject><subject>Monkeys & apes</subject><subject>Oral poliovirus vaccine</subject><subject>Pan paniscus - genetics</subject><subject>Pan troglodytes</subject><subject>Pan troglodytes - genetics</subject><subject>Poliomyelitis vaccine</subject><subject>Poliovirus</subject><subject>Poliovirus - growth & development</subject><subject>Poliovirus Vaccine, Oral - chemistry</subject><subject>Poliovirus vaccines</subject><subject>Polymerase Chain Reaction</subject><subject>Production of active biomolecules</subject><subject>Ribosomal DNA</subject><subject>Simian immunodeficiency virus</subject><subject>Theory</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccins</subject><subject>Virus Cultivation</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0s-LEzEUB_BBFLeunr2IDArqYWc3mfw-1qJ1oVphda_D28ybMks66SYz4P73pnRYqRQtOQTyPgm8l2-WvaTknNJSXkTbYmfxnBKhuWSPsgklRhSmJOxxNiGEyUITJU6yZzHeEpJqhj3NTihlpaSETzLy1Tu0g4OQTztw9xFj7pt8GcDl371rfX4N1rYd5lew3jiMz7MnDbiIL8b9NPv5-dOP2ZdisZxfzqaLwioi-0LJG9CCQ60Yl6YuKS9rZq0ETY3WIDmCNaokqrYUbN0ogkYAQqmJlpRrdpq93727Cf5uwNhX6zZadA469EOsFGel1oqXSb77tyTKMK3FfyFVCTFjEnzzF7z1Q0jjiVVJmdBMyi0626EVOKzarvF9ALvCDtPsfIdNm46nSlBJpd72UxzgadW4bu0h_2HPJ9Ljr34FQ4zV5dW3o-ny-mj6cX4s1fPFHj07RK13DldYpVzMlnv8Ysdt8DEGbKpNaNcQ7itKqm2sqzHW1RjrdOP1-CHDzRrrP37McQJvRwDRgmsCdLaND84InrKS1Kuduo29Dw9VRjQTgrPfEXYCMQ</recordid><startdate>20010427</startdate><enddate>20010427</enddate><creator>Poinar, Hendrik</creator><creator>Kuch, Melanie</creator><creator>Pääbo, Svante</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010427</creationdate><title>Molecular Analyses of Oral Polio Vaccine Samples</title><author>Poinar, Hendrik ; 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Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Kidney - cytology</topic><topic>Mitochondrial DNA</topic><topic>Monkeys & apes</topic><topic>Oral poliovirus vaccine</topic><topic>Pan paniscus - genetics</topic><topic>Pan troglodytes</topic><topic>Pan troglodytes - genetics</topic><topic>Poliomyelitis vaccine</topic><topic>Poliovirus</topic><topic>Poliovirus - growth & development</topic><topic>Poliovirus Vaccine, Oral - chemistry</topic><topic>Poliovirus vaccines</topic><topic>Polymerase Chain Reaction</topic><topic>Production of active biomolecules</topic><topic>Ribosomal DNA</topic><topic>Simian immunodeficiency virus</topic><topic>Theory</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Vaccins</topic><topic>Virus Cultivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poinar, Hendrik</creatorcontrib><creatorcontrib>Kuch, Melanie</creatorcontrib><creatorcontrib>Pääbo, 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The "OPV/AIDS hypothesis" suggests that the OPV used in this campaign was produced in chimpanzee kidney epithelial cell cultures rather than in monkey kidney cell cultures, as stated by H. Koprowski and co-workers, who produced the OPV. If chimpanzee cells were indeed used, this would lend support to the OPV/AIDS hypothesis, since chimpanzees harbor a simian immunodeficiency virus, widely accepted to be the origin of HIV-1. We analyzed several early OPV pools and found no evidence for the presence of chimpanzee DNA; by contrast, monkey DNA is present.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>11326104</pmid><doi>10.1126/science.1058463</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2001-04, Vol.292 (5517), p.743-744 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome (AIDS) AIDS AIDS (Disease) AIDS research Animals Biological and medical sciences Biotechnology Causes and theories of causation Cell Culture Techniques Cells, Cultured Cercopithecidae - genetics Chimpanzees Cultured cells Diseases DNA DNA - analysis DNA - genetics DNA, Mitochondrial - analysis DNA, Mitochondrial - genetics DNA, Ribosomal - analysis DNA, Ribosomal - genetics Drug Contamination Epithelial Cells Etiology (Medicine) Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Human immunodeficiency virus Humans Industrial applications and implications. Economical aspects Kidney - cytology Mitochondrial DNA Monkeys & apes Oral poliovirus vaccine Pan paniscus - genetics Pan troglodytes Pan troglodytes - genetics Poliomyelitis vaccine Poliovirus Poliovirus - growth & development Poliovirus Vaccine, Oral - chemistry Poliovirus vaccines Polymerase Chain Reaction Production of active biomolecules Ribosomal DNA Simian immunodeficiency virus Theory Vaccination Vaccines Vaccins Virus Cultivation |
| title | Molecular Analyses of Oral Polio Vaccine Samples |
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