Rat factor X is synthesized as a single chain precursor inducible by prothrombin fragments

Factor X in plasma is a gamma-carboxylated two-chain glycoprotein which, in activated form, plays a pivotal role in blood coagulation. We have utilized purified rat Factor X antibody, coupled to Sepharose, to isolate and characterize Factor X in rat liver, plasma, and hepatoma cells. Rat factor X is...

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Veröffentlicht in:	The Journal of biological chemistry 1982-11, Vol.257 (21), p.13108-13113
Hauptverfasser:	Graves, C B, Munns, T W, Willingham, A K, Strauss, A W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Electrophoresis, Polyacrylamide Gel Factor X - biosynthesis Factor X - isolation & purification Liver Neoplasms, Experimental - metabolism Peptide Fragments - metabolism Prothrombin - physiology Rats Tunicamycin - pharmacology Vitamin K - pharmacology
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