Mechanisms of Adaptation in a Predator-Prey Arms Race: TTX-Resistant Sodium Channels

Populations of the garter snake Thamnophis sirtalis have evolved geographically variable resistance to tetrodotoxin (TTX) in a coevolutionary arms race with their toxic prey, newts of the genus Taricha. Here, we identify a physiological mechanism, the expression of TTX-resistant sodium channels in s...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-08, Vol.297 (5585), p.1336-1339
Hauptverfasser:	Geffeney, Shana, Brodie, Edmund D., Ruben, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adaptation, Physiological Animal and plant ecology Animal, plant and microbial ecology Animals Arms races Autoecology Biological and medical sciences Biological Evolution Colubridae - physiology Drug Resistance Evolution Evolution (Biology) Fundamental and applied biological sciences. Psychology Garter snakes Garters Genetic variation Individual Differences Linear Models Locomotion - drug effects Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - physiology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Neuromuscular Junction - drug effects Neuromuscular Junction - physiology Newts Physiological aspects Physiology Poisons Population geography Predation Predatory Behavior Reptilia. Amphibia Salamandridae - metabolism Skeletal muscle Skin - chemistry Snakes Sodium channels Sodium Channels - drug effects Sodium Channels - physiology Tetrodotoxin Tetrodotoxin - toxicity United States Vertebrata
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