Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion

Neurotransmitter release is triggered by an increase in the cytosolic Ca 2+ concentration ([Ca 2+ ] i ), but it is unknown whether the Ca 2+ -sensitivity of vesicle fusion is modulated during synaptic plasticity. We investigated whether the potentiation of neurotransmitter release by phorbol esters...

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Veröffentlicht in:	Nature (London) 2005-05, Vol.435 (7041), p.497-501
Hauptverfasser:	Lou, Xuelin, Scheuss, Volker, Schneggenburger, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Animals Biological and medical sciences Brain Stem - cytology Brain Stem - drug effects Brain Stem - physiology Calcium Calcium - metabolism Calcium - pharmacology Calcium Signaling - drug effects Cell physiology Chromaffin Cells - cytology Chromaffin Cells - drug effects Chromaffin Cells - secretion Esters Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Humanities and Social Sciences In Vitro Techniques Ions letter Membrane Fusion - drug effects Models, Biological Molecular and cellular biology multidisciplinary Nervous system Neurotransmission Neurotransmitter Agents - secretion Neurotransmitters Phorbol 12,13-Dibutyrate - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Rats Science Science (multidisciplinary) Synapses - drug effects Synapses - metabolism Synaptic Transmission - drug effects
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