Life and Death Decisions
Screening small molecules for their ability to perturb a cellular pathway, a strategy called forward chemical genetics, can yield unexpected information about other pathway components. This is well illustrated by new work (Jiang et al.), as Nicholson and Thornberry discuss in their Perspective. Disc...
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Veröffentlicht in: | Science (American Association for the Advancement of Science) 2003-01, Vol.299 (5604), p.214-215 |
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creator | Nicholson, Donald W. Thornberry, Nancy A. |
description | Screening small molecules for their ability to perturb a cellular pathway, a strategy called forward chemical genetics, can yield unexpected information about other pathway components. This is well illustrated by new work (Jiang et al.), as Nicholson and Thornberry discuss in their Perspective. Discovery of a small-molecule activator of apoptosis implicated a tumor suppressor protein and an oncoprotein in the regulation of the mitochondrial cell death pathway. |
doi_str_mv | 10.1126/science.1081274 |
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This is well illustrated by new work (Jiang et al.), as Nicholson and Thornberry discuss in their Perspective. Discovery of a small-molecule activator of apoptosis implicated a tumor suppressor protein and an oncoprotein in the regulation of the mitochondrial cell death pathway.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1081274</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington: American Association for the Advancement of Science</publisher><subject>Apoptosis ; Biochemical genetics ; Biochemistry ; Cancer ; Cell death ; Cells ; Cells (Biology) ; Cellular biology ; Cytochromes ; Gene expression regulation ; Genetics ; Medical treatment ; Molecules ; Monomers ; Observations ; Perspectives ; Pharmacology ; Purkinje cells ; rev genes ; Stimuli</subject><ispartof>Science (American Association for the Advancement of Science), 2003-01, Vol.299 (5604), p.214-215</ispartof><rights>Copyright 2003 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 10, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-f92ccb17fdf3a9353eb0be283b0526507c65a66d484c272ac1b1ab7a3d8bf9173</citedby><cites>FETCH-LOGICAL-c526t-f92ccb17fdf3a9353eb0be283b0526507c65a66d484c272ac1b1ab7a3d8bf9173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3833326$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3833326$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids></links><search><creatorcontrib>Nicholson, Donald W.</creatorcontrib><creatorcontrib>Thornberry, Nancy A.</creatorcontrib><title>Life and Death Decisions</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Screening small molecules for their ability to perturb a cellular pathway, a strategy called forward chemical genetics, can yield unexpected information about other pathway components. This is well illustrated by new work (Jiang et al.), as Nicholson and Thornberry discuss in their Perspective. Discovery of a small-molecule activator of apoptosis implicated a tumor suppressor protein and an oncoprotein in the regulation of the mitochondrial cell death pathway.</description><subject>Apoptosis</subject><subject>Biochemical genetics</subject><subject>Biochemistry</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cells</subject><subject>Cells (Biology)</subject><subject>Cellular biology</subject><subject>Cytochromes</subject><subject>Gene expression regulation</subject><subject>Genetics</subject><subject>Medical treatment</subject><subject>Molecules</subject><subject>Monomers</subject><subject>Observations</subject><subject>Perspectives</subject><subject>Pharmacology</subject><subject>Purkinje cells</subject><subject>rev 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subjects | Apoptosis Biochemical genetics Biochemistry Cancer Cell death Cells Cells (Biology) Cellular biology Cytochromes Gene expression regulation Genetics Medical treatment Molecules Monomers Observations Perspectives Pharmacology Purkinje cells rev genes Stimuli |
title | Life and Death Decisions |
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