Trans-kingdom transposition of the Drosophila element mariner within the protozoan Leishmania

Transposable elements of the mariner/Tc1 family are postulated to have spread by horizontal transfer and be relatively independent of host-specific factors. This was tested by introducing the Drosophila mauritiana element mariner into the human parasite Leishmania major, a trypanosomatid protozoan b...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-06, Vol.276 (5319), p.1716-1719
Hauptverfasser:	Gueiros-Filho, F.J. (Harvard Medical School, Boston, MA.), Beverley, S.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence BIOCHIMIE Biological and medical sciences Biological Evolution BIOQUIMICA Cinnamates Classical genetics, quantitative genetics, hybrids Coding Dihydrofolate reductase DNA DNA Nucleotidyltransferases - chemistry DNA Nucleotidyltransferases - genetics DNA Transposable Elements DROSOPHILA Drosophila - genetics Drosophila mauritiana Drug Resistance Duplication Family (Sociological Unit) Fundamental and applied biological sciences. Psychology GENE GENES Genes, Protozoan Genetic transposition GENETICA MOLECULAR Genetics Genetics of eukaryotes. Biological and molecular evolution GENETIQUE MOLECULAIRE Genome, Protozoan Genomes Hygromycin B - analogs & derivatives Hygromycin B - pharmacology Insects LEISHMANIA Leishmania major Leishmania major - drug effects Leishmania major - genetics Mariners Messenger RNA METHODE METODOS Mutagenesis Mutagenesis, Insertional Parasites Pathogens Plasmids Polymerase chain reaction Protozoa RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Protozoan - genetics RNA, Protozoan - metabolism Skilled Workers Species Specificity Transfection Transposases Transposons Tropical diseases
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