Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that for...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2005-04, Vol.308 (5720), p.411-413 |
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| creator | Ting, Stephen B Caddy, Jacinta Hislop, Nikki Wilanowski, Tomasz Auden, Alana Zhao, Lin-lin Ellis, Sarah Kaur, Pritinder Uchida, Yoshikazu Holleran, Walter M Elias, Peter M Cunningham, John M Jane, Stephen M |
| description | The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution. |
| doi_str_mv | 10.1126/science.1107511 |
| format | Article |
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Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1107511</identifier><identifier>PMID: 15831758</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animal cuticle ; Animals ; Binding Sites ; Biological and medical sciences ; Biological Evolution ; Body Weight ; Congenital Impairments ; DNA ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; DNA-Binding Proteins - physiology ; Drosophila ; Embryo, Mammalian - physiology ; Embryonic Development ; Embryos ; Enzymes ; Epidermis ; Epidermis - embryology ; Epidermis - physiology ; Epithelium ; Epithelium - physiology ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Gene expression regulation ; Genetic aspects ; Genetics ; House mouse ; Integrity ; Kruppel-Like Transcription Factors ; Mice ; Molecular and cellular biology ; Mutation ; Permeability ; Physical Disabilities ; Rodents ; Skin ; Tissue engineering ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription Factors - physiology ; Transglutaminases - genetics ; Transglutaminases - metabolism ; Water ; Wound Healing - physiology ; Wounds ; Wounds and injuries ; Zoology</subject><ispartof>Science (American Association for the Advancement of Science), 2005-04, Vol.308 (5720), p.411-413</ispartof><rights>Copyright 2005 American Association for the Advancement of Science</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Apr 15, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c741t-9c2d90760a36cf3d56173ca5dcf22e0911bb6f4a8b5689f89721af9c83841c8f3</citedby><cites>FETCH-LOGICAL-c741t-9c2d90760a36cf3d56173ca5dcf22e0911bb6f4a8b5689f89721af9c83841c8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3841250$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3841250$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16708217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15831758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ting, Stephen B</creatorcontrib><creatorcontrib>Caddy, Jacinta</creatorcontrib><creatorcontrib>Hislop, Nikki</creatorcontrib><creatorcontrib>Wilanowski, Tomasz</creatorcontrib><creatorcontrib>Auden, Alana</creatorcontrib><creatorcontrib>Zhao, Lin-lin</creatorcontrib><creatorcontrib>Ellis, Sarah</creatorcontrib><creatorcontrib>Kaur, Pritinder</creatorcontrib><creatorcontrib>Uchida, Yoshikazu</creatorcontrib><creatorcontrib>Holleran, Walter M</creatorcontrib><creatorcontrib>Elias, Peter M</creatorcontrib><creatorcontrib>Cunningham, John M</creatorcontrib><creatorcontrib>Jane, Stephen M</creatorcontrib><title>Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.</description><subject>Animal cuticle</subject><subject>Animals</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Body Weight</subject><subject>Congenital Impairments</subject><subject>DNA</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Drosophila</subject><subject>Embryo, Mammalian - physiology</subject><subject>Embryonic Development</subject><subject>Embryos</subject><subject>Enzymes</subject><subject>Epidermis</subject><subject>Epidermis - embryology</subject><subject>Epidermis - physiology</subject><subject>Epithelium</subject><subject>Epithelium - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Gene expression regulation</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>House mouse</subject><subject>Integrity</subject><subject>Kruppel-Like Transcription Factors</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Mutation</subject><subject>Permeability</subject><subject>Physical Disabilities</subject><subject>Rodents</subject><subject>Skin</subject><subject>Tissue engineering</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription Factors - physiology</subject><subject>Transglutaminases - genetics</subject><subject>Transglutaminases - metabolism</subject><subject>Water</subject><subject>Wound Healing - physiology</subject><subject>Wounds</subject><subject>Wounds and 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physiology</topic><topic>Drosophila</topic><topic>Embryo, Mammalian - physiology</topic><topic>Embryonic Development</topic><topic>Embryos</topic><topic>Enzymes</topic><topic>Epidermis</topic><topic>Epidermis - embryology</topic><topic>Epidermis - physiology</topic><topic>Epithelium</topic><topic>Epithelium - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Gene expression regulation</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>House mouse</topic><topic>Integrity</topic><topic>Kruppel-Like Transcription Factors</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Mutation</topic><topic>Permeability</topic><topic>Physical Disabilities</topic><topic>Rodents</topic><topic>Skin</topic><topic>Tissue engineering</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription Factors - physiology</topic><topic>Transglutaminases - genetics</topic><topic>Transglutaminases - metabolism</topic><topic>Water</topic><topic>Wound Healing - physiology</topic><topic>Wounds</topic><topic>Wounds and injuries</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ting, Stephen B</creatorcontrib><creatorcontrib>Caddy, 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Science)</jtitle><addtitle>Science</addtitle><date>2005-04-15</date><risdate>2005</risdate><volume>308</volume><issue>5720</issue><spage>411</spage><epage>413</epage><pages>411-413</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly. Integral to cuticle resilience is the transcription factor grainy head, which regulates production of the enzyme required for covalent cross-linking of the cuticular structural components. We report that formation and maintenance of the epidermal barrier in mice are dependent on a mammalian homolog of grainy head, Grainy head-like 3. Mice lacking this factor display defective skin barrier function and deficient wound repair, accompanied by reduced expression of transglutaminase 1, the key enzyme involved in cross-linking the structural components of the superficial epidermis. These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>15831758</pmid><doi>10.1126/science.1107511</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2005-04, Vol.308 (5720), p.411-413 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743232396 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Animal cuticle Animals Binding Sites Biological and medical sciences Biological Evolution Body Weight Congenital Impairments DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Drosophila Embryo, Mammalian - physiology Embryonic Development Embryos Enzymes Epidermis Epidermis - embryology Epidermis - physiology Epithelium Epithelium - physiology Fundamental and applied biological sciences. Psychology Gene Expression Gene expression regulation Genetic aspects Genetics House mouse Integrity Kruppel-Like Transcription Factors Mice Molecular and cellular biology Mutation Permeability Physical Disabilities Rodents Skin Tissue engineering Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transglutaminases - genetics Transglutaminases - metabolism Water Wound Healing - physiology Wounds Wounds and injuries Zoology |
| title | Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A17%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Homolog%20of%20Drosophila%20grainy%20head%20Is%20Essential%20for%20Epidermal%20Integrity%20in%20Mice&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Ting,%20Stephen%20B&rft.date=2005-04-15&rft.volume=308&rft.issue=5720&rft.spage=411&rft.epage=413&rft.pages=411-413&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1107511&rft_dat=%3Cgale_proqu%3EA132052961%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213593985&rft_id=info:pmid/15831758&rft_galeid=A132052961&rft_jstor_id=3841250&rfr_iscdi=true |