Malignant Melanoma of the Gallbladder
A rare case of primary malignant melanoma of the gallbladder was studied with the electron microscope. Two interesting patterns were observed: numerous melanophages were present in the tumor tissue and wrapped compound melanosomes were found in nonneoplastic mucosal epithelium. The infiltration of m...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 1978-11, Vol.163 (3), p.281-287 |
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| container_title | Pathology, research and practice |
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| creator | Hatae, Y. Kikuchi, M. Segawa, M. Yonemitsu, K. |
| description | A rare case of primary malignant melanoma of the gallbladder was studied with the electron microscope. Two interesting patterns were observed: numerous melanophages were present in the tumor tissue and wrapped compound melanosomes were found in nonneoplastic mucosal epithelium. The infiltration of melanophages was considered to be a reaction to degenerated tumor cells. Concerning the mechanism of melanosome transport into the epithelial cells, a cooperative action between epithelial and melanoma cells seemed to be the most important factor. |
| doi_str_mv | 10.1016/S0344-0338(78)80021-1 |
| format | Article |
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Two interesting patterns were observed: numerous melanophages were present in the tumor tissue and wrapped compound melanosomes were found in nonneoplastic mucosal epithelium. The infiltration of melanophages was considered to be a reaction to degenerated tumor cells. Concerning the mechanism of melanosome transport into the epithelial cells, a cooperative action between epithelial and melanoma cells seemed to be the most important factor.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/S0344-0338(78)80021-1</identifier><identifier>PMID: 733645</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Aged ; Electron microscopy ; Epithelium - ultrastructure ; Gallbladder ; Gallbladder Neoplasms - pathology ; Gallbladder Neoplasms - ultrastructure ; Humans ; Male ; Malignant melanoma ; Melanoma - pathology ; Melanoma - ultrastructure ; Microscopy, Electron</subject><ispartof>Pathology, research and practice, 1978-11, Vol.163 (3), p.281-287</ispartof><rights>1978 Gustav Fischer Verlag, Stuttgart/New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-373f182feeb0b8e84a90f62fc43188be1e1d146ede41909f994787d88e1623653</citedby><cites>FETCH-LOGICAL-c359t-373f182feeb0b8e84a90f62fc43188be1e1d146ede41909f994787d88e1623653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033878800211$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/733645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hatae, Y.</creatorcontrib><creatorcontrib>Kikuchi, M.</creatorcontrib><creatorcontrib>Segawa, M.</creatorcontrib><creatorcontrib>Yonemitsu, K.</creatorcontrib><title>Malignant Melanoma of the Gallbladder</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>A rare case of primary malignant melanoma of the gallbladder was studied with the electron microscope. Two interesting patterns were observed: numerous melanophages were present in the tumor tissue and wrapped compound melanosomes were found in nonneoplastic mucosal epithelium. The infiltration of melanophages was considered to be a reaction to degenerated tumor cells. Concerning the mechanism of melanosome transport into the epithelial cells, a cooperative action between epithelial and melanoma cells seemed to be the most important factor.</description><subject>Aged</subject><subject>Electron microscopy</subject><subject>Epithelium - ultrastructure</subject><subject>Gallbladder</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gallbladder Neoplasms - ultrastructure</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant melanoma</subject><subject>Melanoma - pathology</subject><subject>Melanoma - ultrastructure</subject><subject>Microscopy, Electron</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC3EqxT-AUi9gOAQ2I0d2zkhVEFBasUBOFtOsoagPIqdIvHvSUnVK6c9zMzO7sfYGcI1AsqbF-BCRMC5vlT6SgPEGOEOG6FEHYHkuMtGW8shOwrhEwAUCDxg-4pzKZIRO1_YqnxvbNNNFlTZpq3tpHWT7oMmM1tVWWWLgvwx23O2CnSymWP29nD_On2M5s-zp-ndPMp5knYRV9yhjh1RBpkmLWwKTsYuFxy1zggJCxSSChKYQurSVCitCq0JZcxlwsfsYti79O3XikJn6jLkVPWHUbsKRgke8xjWxmQw5r4NwZMzS1_W1v8YBLOmY_7omPXrRmnzR8dgnzvdFKyymoptasDRy7eDTP2T3yV5E_KSmpyK0lPemaIt_yn4BSLRcX8</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Hatae, Y.</creator><creator>Kikuchi, M.</creator><creator>Segawa, M.</creator><creator>Yonemitsu, K.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197811</creationdate><title>Malignant Melanoma of the Gallbladder</title><author>Hatae, Y. ; Kikuchi, M. ; Segawa, M. ; Yonemitsu, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-373f182feeb0b8e84a90f62fc43188be1e1d146ede41909f994787d88e1623653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Aged</topic><topic>Electron microscopy</topic><topic>Epithelium - ultrastructure</topic><topic>Gallbladder</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gallbladder Neoplasms - ultrastructure</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant melanoma</topic><topic>Melanoma - pathology</topic><topic>Melanoma - ultrastructure</topic><topic>Microscopy, Electron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hatae, Y.</creatorcontrib><creatorcontrib>Kikuchi, M.</creatorcontrib><creatorcontrib>Segawa, M.</creatorcontrib><creatorcontrib>Yonemitsu, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hatae, Y.</au><au>Kikuchi, M.</au><au>Segawa, M.</au><au>Yonemitsu, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant Melanoma of the Gallbladder</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>1978-11</date><risdate>1978</risdate><volume>163</volume><issue>3</issue><spage>281</spage><epage>287</epage><pages>281-287</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>A rare case of primary malignant melanoma of the gallbladder was studied with the electron microscope. Two interesting patterns were observed: numerous melanophages were present in the tumor tissue and wrapped compound melanosomes were found in nonneoplastic mucosal epithelium. The infiltration of melanophages was considered to be a reaction to degenerated tumor cells. Concerning the mechanism of melanosome transport into the epithelial cells, a cooperative action between epithelial and melanoma cells seemed to be the most important factor.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>733645</pmid><doi>10.1016/S0344-0338(78)80021-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Pathology, research and practice, 1978-11, Vol.163 (3), p.281-287 |
| issn | 0344-0338 1618-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Electron microscopy Epithelium - ultrastructure Gallbladder Gallbladder Neoplasms - pathology Gallbladder Neoplasms - ultrastructure Humans Male Malignant melanoma Melanoma - pathology Melanoma - ultrastructure Microscopy, Electron |
| title | Malignant Melanoma of the Gallbladder |
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