Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consist...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2004-04, Vol.304 (5669), p.445-448 |
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| creator | Singer, Jonathan B. Hill, Annie E. Burrage, Lindsay C. Olszens, Keith R. Song, Junghan Justice, Monica O'Brien, William E. Conti, David V. Witte, John S. Lander, Eric S. Nadeau, Joseph H. |
| description | Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains. |
| doi_str_mv | 10.1126/science.1093139 |
| format | Article |
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Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1093139</identifier><identifier>PMID: 15031436</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Amino Acids - blood ; Animals ; Anxiety - genetics ; Biological and medical sciences ; Chromosome Mapping ; Chromosomes ; Chromosomes, Mammalian - genetics ; Classical genetics, quantitative genetics, hybrids ; Congenic strains ; Crosses, Genetic ; Diet ; Donors ; Expectation ; Female ; Fundamental and applied biological sciences. 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Biological and molecular evolution ; Genomes ; House mouse ; Ideography ; Male ; Medical genetics ; Methods ; Mice ; Mice, Inbred A ; Mice, Inbred C57BL ; Microsatellite Repeats ; Molecular genetics ; Obesity ; Obesity - genetics ; Obesity - physiopathology ; Parasitism ; Phenotype ; Phenotypic traits ; Quantitative Trait Loci ; Quantitative Trait, Heritable ; Research universities ; Rodents ; Sterols - blood ; Vertebrata ; Weight Gain</subject><ispartof>Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5669), p.445-448</ispartof><rights>Copyright 2004 American Association for the Advancement of Science</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2004 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Apr 16, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c817t-269678521218855d0dd8e65e00e0312d1ad8dc695003c1aafbda50177d7551793</citedby><cites>FETCH-LOGICAL-c817t-269678521218855d0dd8e65e00e0312d1ad8dc695003c1aafbda50177d7551793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3836674$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3836674$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15753387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15031436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singer, Jonathan B.</creatorcontrib><creatorcontrib>Hill, Annie E.</creatorcontrib><creatorcontrib>Burrage, Lindsay C.</creatorcontrib><creatorcontrib>Olszens, Keith R.</creatorcontrib><creatorcontrib>Song, Junghan</creatorcontrib><creatorcontrib>Justice, Monica</creatorcontrib><creatorcontrib>O'Brien, William E.</creatorcontrib><creatorcontrib>Conti, David V.</creatorcontrib><creatorcontrib>Witte, John S.</creatorcontrib><creatorcontrib>Lander, Eric S.</creatorcontrib><creatorcontrib>Nadeau, Joseph H.</creatorcontrib><title>Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.</description><subject>Amino Acids - blood</subject><subject>Animals</subject><subject>Anxiety - genetics</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Mammalian - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Congenic strains</subject><subject>Crosses, Genetic</subject><subject>Diet</subject><subject>Donors</subject><subject>Expectation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>15031436</pmid><doi>10.1126/science.1093139</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5669), p.445-448 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743219997 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Amino Acids - blood Animals Anxiety - genetics Biological and medical sciences Chromosome Mapping Chromosomes Chromosomes, Mammalian - genetics Classical genetics, quantitative genetics, hybrids Congenic strains Crosses, Genetic Diet Donors Expectation Female Fundamental and applied biological sciences. Psychology Genes Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genomes House mouse Ideography Male Medical genetics Methods Mice Mice, Inbred A Mice, Inbred C57BL Microsatellite Repeats Molecular genetics Obesity Obesity - genetics Obesity - physiopathology Parasitism Phenotype Phenotypic traits Quantitative Trait Loci Quantitative Trait, Heritable Research universities Rodents Sterols - blood Vertebrata Weight Gain |
| title | Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T00%3A08%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Dissection%20of%20Complex%20Traits%20with%20Chromosome%20Substitution%20Strains%20of%20Mice&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Singer,%20Jonathan%20B.&rft.date=2004-04-16&rft.volume=304&rft.issue=5669&rft.spage=445&rft.epage=448&rft.pages=445-448&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1093139&rft_dat=%3Cgale_proqu%3EA116185016%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213587640&rft_id=info:pmid/15031436&rft_galeid=A116185016&rft_jstor_id=3836674&rfr_iscdi=true |