Finding Functional Features in Saccharomyces Genomes by Phylogenetic Footprinting

The sifting and winnowing of DNA sequence that occur during evolution cause nonfunctional sequences to diverge, leaving phylogenetic footprints of functional sequence elements in comparisons of genome sequences. We searched for such footprints among the genome sequences of six Saccharomyces species...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-07, Vol.301 (5629), p.71-76
Hauptverfasser:	Cliften, Paul, Sudarsanam, Priya, Desikan, Ashwin, Fulton, Lucinda, Fulton, Bob, Majors, John, Waterston, Robert, Cohen, Barak A., Johnston, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Base Sequence Binding Sites Biological and medical sciences Cell cycle Coding Comparative Analysis Computational Biology Conserved Sequence Conserved sequences DNA damage DNA, Intergenic Evolution Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genes Genes, Fungal Genetic aspects Genome, Fungal Genomes Genomics Intergenic DNA Molecular and cellular biology Molecular Sequence Data Motifs Open reading frames Phylogeny Regulatory Sequences, Nucleic Acid Saccharomyces Saccharomyces - classification Saccharomyces - genetics Saccharomyces - physiology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - physiology Sequence Alignment Sequence Analysis, DNA Transcription factors Transcription Factors - metabolism Yeast
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