Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polym...
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| Veröffentlicht in: | Nature (London) 1992-05, Vol.357 (6375), p.211-215 |
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| container_title | Nature (London) |
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| creator | Powis, Simon J Deverson, Edward V Coadweil, W. John Ciruela, Antonio Huskisson, Neville S Smith, Howard Butcher, Geoffrey W Howard, Jonathan C |
| description | Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides. |
| doi_str_mv | 10.1038/357211a0 |
| format | Article |
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John ; Ciruela, Antonio ; Huskisson, Neville S ; Smith, Howard ; Butcher, Geoffrey W ; Howard, Jonathan C</creator><creatorcontrib>Powis, Simon J ; Deverson, Edward V ; Coadweil, W. John ; Ciruela, Antonio ; Huskisson, Neville S ; Smith, Howard ; Butcher, Geoffrey W ; Howard, Jonathan C</creatorcontrib><description>Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/357211a0</identifier><identifier>PMID: 1350326</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alleles ; Amino Acid Sequence ; Animals ; antigen presentation ; Biological and medical sciences ; Carrier Proteins - biosynthesis ; Carrier Proteins - genetics ; Cell Line ; Cellular biology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; genes ; Genes, MHC Class I ; Genetics ; Genetics of the immune response ; histocompatibility antigen RT1 ; Histocompatibility Antigens Class I - biosynthesis ; Histocompatibility Antigens Class I - genetics ; Humanities and Social Sciences ; Humans ; Immunity (Disease) ; Immunobiology ; Kinetics ; Lymphoma, T-Cell ; Major Histocompatibility Complex ; Membrane Proteins - biosynthesis ; Membrane Proteins - genetics ; Membrane Transport Proteins ; Molecular Sequence Data ; Molecules ; mtp2 gene ; Mtp2 protein ; multidisciplinary ; Peptides ; Poly A - genetics ; Polymerase Chain Reaction - methods ; Polymorphism, Genetic ; prediction ; Protein Conformation ; Proteins ; Rats ; RNA, Messenger - genetics ; Science ; Science (multidisciplinary) ; Sequence Homology, Nucleic Acid ; Transfection</subject><ispartof>Nature (London), 1992-05, Vol.357 (6375), p.211-215</ispartof><rights>Springer Nature Limited 1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. May 21, 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-21a84d83c8aba5b1ff2dff2b17559ff445706d06478477d96c7794932f9b162c3</citedby><cites>FETCH-LOGICAL-c520t-21a84d83c8aba5b1ff2dff2b17559ff445706d06478477d96c7794932f9b162c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5483871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1350326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Powis, Simon J</creatorcontrib><creatorcontrib>Deverson, Edward V</creatorcontrib><creatorcontrib>Coadweil, W. 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Psychology</subject><subject>Fundamental immunology</subject><subject>genes</subject><subject>Genes, MHC Class I</subject><subject>Genetics</subject><subject>Genetics of the immune response</subject><subject>histocompatibility antigen RT1</subject><subject>Histocompatibility Antigens Class I - biosynthesis</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Immunobiology</subject><subject>Kinetics</subject><subject>Lymphoma, T-Cell</subject><subject>Major Histocompatibility Complex</subject><subject>Membrane Proteins - biosynthesis</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Molecular Sequence Data</subject><subject>Molecules</subject><subject>mtp2 gene</subject><subject>Mtp2 protein</subject><subject>multidisciplinary</subject><subject>Peptides</subject><subject>Poly A - genetics</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Polymorphism, Genetic</subject><subject>prediction</subject><subject>Protein Conformation</subject><subject>Proteins</subject><subject>Rats</subject><subject>RNA, Messenger - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transfection</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0c2L1TAQAPAgyvpcBf8BJYj4cajmO-lRHqu7sOJFzyVNJ27XNKlJe9j_3ix9vgURPYSQzI-ZSQahp5S8o4Sb91xqRqkl99COCq0aoYy-j3aEMNMQw9VD9KiUa0KIpFqcoBPKJeFM7ZA78x7cgpPHcwo3U8rz1Vim27ON-PP5vglj_AEDXrKNZU55gYxTxMsV4BnmZRygYFsKTH2oaozYYhfqBb7AUwrg1gCP0QNvQ4Enh_0Ufft49nV_3lx--XSx_3DZOMnI0jBqjRgMd8b2VvbUezbU1VMtZeu9EFITNRAltBFaD61yWrei5cy3PVXM8VP0ess75_RzhbJ001gchGAjpLV0WnDaaiNZla_-LVmr6g-J_8JalwqpZIUv_oDXac2xPrdjpLauWq0rerMhl1MpGXw353Gy-aajpLudY_d7jpU-O-Rb-wmGO7gNrsZfHuK2OBt8nY4by5FJYbjRtLK3Gys1Er9DvmvrLyWfbzbaZc1wzHUEvwBnerkV</recordid><startdate>19920521</startdate><enddate>19920521</enddate><creator>Powis, Simon J</creator><creator>Deverson, Edward V</creator><creator>Coadweil, W. 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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1992-05, Vol.357 (6375), p.211-215 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Springer Nature - Connect here FIRST to enable access; Alma/SFX Local Collection |
| subjects | Alleles Amino Acid Sequence Animals antigen presentation Biological and medical sciences Carrier Proteins - biosynthesis Carrier Proteins - genetics Cell Line Cellular biology Fundamental and applied biological sciences. Psychology Fundamental immunology genes Genes, MHC Class I Genetics Genetics of the immune response histocompatibility antigen RT1 Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Humanities and Social Sciences Humans Immunity (Disease) Immunobiology Kinetics Lymphoma, T-Cell Major Histocompatibility Complex Membrane Proteins - biosynthesis Membrane Proteins - genetics Membrane Transport Proteins Molecular Sequence Data Molecules mtp2 gene Mtp2 protein multidisciplinary Peptides Poly A - genetics Polymerase Chain Reaction - methods Polymorphism, Genetic prediction Protein Conformation Proteins Rats RNA, Messenger - genetics Science Science (multidisciplinary) Sequence Homology, Nucleic Acid Transfection |
| title | Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule |
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