Direct Link between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense

Major histocompatibility complex (mhc)-encoded molecules govern immune responses by presenting antigenic peptides to T cells. The extensive polymorphism of genes encoding these molecules is believed to enhance immune defense by broadening the array of antigenic peptides available for T cell recognit...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-11, Vol.298 (5599), p.1797-1800
Hauptverfasser:	Messaoudi, Ilhem, Jose A. Guevara Patiño, Dyall, Ruben, LeMaoult, Joël, Nikolich-Žugich, Janko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Analysis Animals Antivirals Biological and medical sciences Cells Chemical polymorphism Communicable Diseases Complementarity Determining Regions Cytotoxicity, Immunologic Dosage Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, MHC Class I H-2 Antigens - genetics H-2 Antigens - immunology Haplotypes Herpes Simplex - immunology Herpesvirus 1, Human - immunology Histocompatibility Immune system Immunity, Innate Immunobiology Immunologic tolerance Immunological tolerance Infections Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Mice Mice, Inbred C57BL Mice, Inbred Strains Molecules Pathogens Peptides Polymorphism (Crystallography) Polymorphism, Genetic Receptors, Antigen, T-Cell, alpha-beta - immunology T cell antigen receptors T cells T lymphocytes T-Lymphocytes, Cytotoxic - immunology Viruses
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