Adaptation in the chemotactic guidance of nerve growth cones
Pathfinding by growing axons in the developing nervous system may be guided by gradients of extracellular guidance factors. Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration,...
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| Veröffentlicht in: | Nature (London) 2002-05, Vol.417 (6887), p.411-418 |
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| creator | MING, Guo-Ii WONG, Scoff T HENLEY, John YUAN, Xiao-Bing SONG, Hong-Jun SPITZER, Nicholas C POO, Mu-Ming |
| description | Pathfinding by growing axons in the developing nervous system may be guided by gradients of extracellular guidance factors. Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration, undergoing consecutive phases of desensitization and resensitization in the presence of increasing basal concentrations of the guidance factor netrin-1 or brain-derived neurotrophic factor. The desensitization is specific to the guidance factor and is accompanied by a reduction of Ca2+ signalling, whereas resensitization requires activation of mitogen-associated protein kinase and local protein synthesis. Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis. |
| doi_str_mv | 10.1038/nature745 |
| format | Article |
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Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration, undergoing consecutive phases of desensitization and resensitization in the presence of increasing basal concentrations of the guidance factor netrin-1 or brain-derived neurotrophic factor. The desensitization is specific to the guidance factor and is accompanied by a reduction of Ca2+ signalling, whereas resensitization requires activation of mitogen-associated protein kinase and local protein synthesis. Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature745</identifier><identifier>PMID: 11986620</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Adaptation, Biological - drug effects ; Animals ; Biological and medical sciences ; Brain ; Brain-Derived Neurotrophic Factor - pharmacology ; Calcium Signaling - drug effects ; Cell Size - drug effects ; Chemotaxis - drug effects ; Chick Embryo ; Development. Senescence. Regeneration. Transplantation ; Enzyme Activation - drug effects ; Fundamental and applied biological sciences. Psychology ; Growth Cones - drug effects ; Growth Cones - enzymology ; Growth Cones - physiology ; Microorganisms ; Mitogen-Activated Protein Kinases - metabolism ; Nerve Growth Factors - metabolism ; Nerve Growth Factors - pharmacology ; Nervous system ; Netrin 1 ; Netrin Receptors ; Neurology ; Neurons ; Protein synthesis ; Protein Synthesis Inhibitors - pharmacology ; Receptors, Cell Surface - metabolism ; Reptiles & amphibians ; Spinal Cord - cytology ; Spinal Cord - embryology ; Tumor Suppressor Proteins ; Vertebrates: nervous system and sense organs ; Xenopus ; Xenopus - embryology ; Xenopus - physiology</subject><ispartof>Nature (London), 2002-05, Vol.417 (6887), p.411-418</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. 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| ispartof | Nature (London), 2002-05, Vol.417 (6887), p.411-418 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature; SpringerNature Complete Journals |
| subjects | Adaptation, Biological - drug effects Animals Biological and medical sciences Brain Brain-Derived Neurotrophic Factor - pharmacology Calcium Signaling - drug effects Cell Size - drug effects Chemotaxis - drug effects Chick Embryo Development. Senescence. Regeneration. Transplantation Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Growth Cones - drug effects Growth Cones - enzymology Growth Cones - physiology Microorganisms Mitogen-Activated Protein Kinases - metabolism Nerve Growth Factors - metabolism Nerve Growth Factors - pharmacology Nervous system Netrin 1 Netrin Receptors Neurology Neurons Protein synthesis Protein Synthesis Inhibitors - pharmacology Receptors, Cell Surface - metabolism Reptiles & amphibians Spinal Cord - cytology Spinal Cord - embryology Tumor Suppressor Proteins Vertebrates: nervous system and sense organs Xenopus Xenopus - embryology Xenopus - physiology |
| title | Adaptation in the chemotactic guidance of nerve growth cones |
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