Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Parkinson's disease is a widespread condition caused by the loss of midbrain neurons that synthesize the neurotransmitter dopamine. Cells derived from the fetal midbrain can modify the course of the disease, but they are an inadequate source of dopamine-synthesizing neurons because their abilit...

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Veröffentlicht in:	Nature (London) 2002-07, Vol.418 (6893), p.50-56
Hauptverfasser:	McKay, Ron, Kim, Jong-Hoon, Auerbach, Jonathan M, Rodríguez-Gómez, José A, Velasco, Iván, Gavin, Denise, Lumelsky, Nadya, Lee, Sang-Hun, Nguyen, John, Sánchez-Pernaute, Rosario, Bankiewicz, Krys
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal diseases Animal models Animals Blotting, Western Brain Cell Differentiation Cell- and Tissue-Based Therapy - methods Chromatography, High Pressure Liquid Disease Models, Animal DNA-Binding Proteins Dopamine - metabolism Electrophysiology Embryo, Mammalian - cytology Embryos Female Mesencephalon - cytology Mesencephalon - metabolism Mesencephalon - pathology Neostriatum - cytology Neostriatum - metabolism Neurons Neurons - cytology Neurons - metabolism Neurons - pathology Neurons - transplantation Nuclear Receptor Subfamily 4, Group A, Member 2 Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - therapy Parkinson's disease Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Stem Cell Transplantation Stem cells Stem Cells - cytology Stem Cells - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transfection
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