Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP$^{40}
After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 part...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1991-10, Vol.254 (5031), p.558-562 |
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| creator | Ullman, Katharine S. Flanagan, W. Michael Edwards, Cynthia A. Crabtree, Gerald R. |
| description | After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP$^{40}$). In addition to interacting specifically with DNA, OAP$^{40}$ reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP$^{40}$. |
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Michael ; Edwards, Cynthia A. ; Crabtree, Gerald R.</creator><creatorcontrib>Ullman, Katharine S. ; Flanagan, W. Michael ; Edwards, Cynthia A. ; Crabtree, Gerald R.</creatorcontrib><description>After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP$^{40}$). 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In addition to interacting specifically with DNA, OAP$^{40}$ reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP$^{40}$.</description><subject>Amino acids</subject><subject>Antiserum</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gels</subject><subject>Genes</subject><subject>Genetic mutation</subject><subject>Genetics</subject><subject>Histones</subject><subject>Immunity (Disease)</subject><subject>Medical research</subject><subject>Oligonucleotides</subject><subject>Proteins</subject><subject>T lymphocytes</subject><subject>Transfection</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdjs9LwzAAhYMoOKf_gYcgghcL-dmmxzHmHAy2w7xakjTFlC6pSSoW8X-3Mk8eHu_wPh7fGZhhVPKsJIiegxlCNM8EKvgluIqxRWjaSjoDcqGT_ZDJegd9A1cydCNcG2fg6rMPJsbfwTp4gNvx2L95PSYToRrhTqcMQ-nqKXDj6kFb1Rm4Dz4Z6x7hbrG_f_1i6PsaXDSyi-bmr-fg5Wl1WD5n2916s1xssxYzkTKKa0KNlGVBkZpEG6YpJoJjmRuha4IFYxQRXvOy0VjQusZGNUaonCkihaJz8HD67YN_H0xM1dFGbbpOOuOHWBWMYp7nLJ_Iu39k64fgJrmKYMq5YJxM0O0JamPyoeqDPcowVkQUJRUF_QHCpmbL</recordid><startdate>19911025</startdate><enddate>19911025</enddate><creator>Ullman, Katharine S.</creator><creator>Flanagan, W. 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Michael</au><au>Edwards, Cynthia A.</au><au>Crabtree, Gerald R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP$^{40}</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><date>1991-10-25</date><risdate>1991</risdate><volume>254</volume><issue>5031</issue><spage>558</spage><epage>562</epage><pages>558-562</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP$^{40}$). In addition to interacting specifically with DNA, OAP$^{40}$ reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP$^{40}$.</abstract><cop>Washington</cop><pub>American Society for the Advancement of Science</pub><tpages>5</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 1991-10, Vol.254 (5031), p.558-562 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Amino acids Antiserum Deoxyribonucleic acid DNA Gels Genes Genetic mutation Genetics Histones Immunity (Disease) Medical research Oligonucleotides Proteins T lymphocytes Transfection |
| title | Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP$^{40} |
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