Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks

RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site). The nuclease activity is then attenuated...

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Veröffentlicht in:	Nature (London) 2004-11, Vol.432 (7014), p.187-193
Hauptverfasser:	Singleton, Martin R., Dillingham, Mark S., Gaudier, Martin, Kowalczykowski, Stephen C., Wigley, Dale B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Crystal structure Crystalline structure Crystallization Crystallography, X-Ray Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA - metabolism DNA Damage DNA Helicases - chemistry DNA Helicases - metabolism DNA Repair Endonucleases - chemistry Endonucleases - metabolism Enzymes Escherichia coli - enzymology Exodeoxyribonuclease V - chemistry Exodeoxyribonuclease V - metabolism Fundamental and applied biological sciences. Psychology Genetics Humanities and Social Sciences Models, Molecular Molecular biophysics multidisciplinary Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Nucleic Acid Conformation Protein Conformation Science Science (multidisciplinary) Structure in molecular biology Structure-Activity Relationship Substrate Specificity
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