Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle
1. Certain marine sponges and dorid nudibranchs contain adenosine, 2-methoxyadenosine, 2′-deoxyadenosine, isoguanosine and 1-methylisoguanosine as free ribosbides. 2. These ribosides have negative inotropic and chronotropic activity on the isolated guinea-pig atria. The decreasing order of activity...
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| Veröffentlicht in: | Comparative biochemistry and physiology. C, Comparative pharmacology Comparative pharmacology, 1982, Vol.72 (2), p.203-210 |
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| container_title | Comparative biochemistry and physiology. C, Comparative pharmacology |
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| creator | Fuhrman, Frederick A. Fuhrman, Geraldine J. |
| description | 1. Certain marine sponges and dorid nudibranchs contain adenosine, 2-methoxyadenosine, 2′-deoxyadenosine, isoguanosine and 1-methylisoguanosine as free ribosbides.
2. These ribosides have negative inotropic and chronotropic activity on the isolated guinea-pig atria. The decreasing order of activity is isoguanosine > 1-methylisoguanosine > adenosine > 2-methyoxyadenosine > 2′-deoxyadenosine.
3. Adenosine and 1-methylisoguanosine inhibit the spontaneous contractions of the rabbit ileum and this effect is antagonized by theophylline.
4. All these naturally-occurring purine ribosides appear to act on the same purinergic receptors in the atria, since log concentration-response curves are parallel.
5. Theophylline is a competitive antagonist of adenosine, isoguanosine and 1-methylisoguanosine on the guinea-pig atria. |
| doi_str_mv | 10.1016/0306-4492(82)90085-5 |
| format | Article |
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2. These ribosides have negative inotropic and chronotropic activity on the isolated guinea-pig atria. The decreasing order of activity is isoguanosine > 1-methylisoguanosine > adenosine > 2-methyoxyadenosine > 2′-deoxyadenosine.
3. Adenosine and 1-methylisoguanosine inhibit the spontaneous contractions of the rabbit ileum and this effect is antagonized by theophylline.
4. All these naturally-occurring purine ribosides appear to act on the same purinergic receptors in the atria, since log concentration-response curves are parallel.
5. Theophylline is a competitive antagonist of adenosine, isoguanosine and 1-methylisoguanosine on the guinea-pig atria.</description><identifier>ISSN: 0306-4492</identifier><identifier>DOI: 10.1016/0306-4492(82)90085-5</identifier><identifier>PMID: 6128140</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adenosine - analogs & derivatives ; Adenosine - pharmacology ; Animals ; Guanosine - analogs & derivatives ; Guanosine - pharmacology ; Guinea Pigs ; Heart - drug effects ; In Vitro Techniques ; Invertebrates - metabolism ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscles - metabolism ; Purine Nucleosides - antagonists & inhibitors ; Purine Nucleosides - pharmacology ; Receptors, Drug - drug effects ; Receptors, Purinergic ; Theophylline - pharmacology</subject><ispartof>Comparative biochemistry and physiology. C, Comparative pharmacology, 1982, Vol.72 (2), p.203-210</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-13c2ce6547862b56bf6685952e51d3ac188836e9c5bc0469c62b2eeff0fc0143</citedby><cites>FETCH-LOGICAL-c357t-13c2ce6547862b56bf6685952e51d3ac188836e9c5bc0469c62b2eeff0fc0143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6128140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuhrman, Frederick A.</creatorcontrib><creatorcontrib>Fuhrman, Geraldine J.</creatorcontrib><title>Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle</title><title>Comparative biochemistry and physiology. C, Comparative pharmacology</title><addtitle>Comp Biochem Physiol C</addtitle><description>1. Certain marine sponges and dorid nudibranchs contain adenosine, 2-methoxyadenosine, 2′-deoxyadenosine, isoguanosine and 1-methylisoguanosine as free ribosbides.
2. These ribosides have negative inotropic and chronotropic activity on the isolated guinea-pig atria. The decreasing order of activity is isoguanosine > 1-methylisoguanosine > adenosine > 2-methyoxyadenosine > 2′-deoxyadenosine.
3. Adenosine and 1-methylisoguanosine inhibit the spontaneous contractions of the rabbit ileum and this effect is antagonized by theophylline.
4. All these naturally-occurring purine ribosides appear to act on the same purinergic receptors in the atria, since log concentration-response curves are parallel.
5. Theophylline is a competitive antagonist of adenosine, isoguanosine and 1-methylisoguanosine on the guinea-pig atria.</description><subject>Adenosine - analogs & derivatives</subject><subject>Adenosine - pharmacology</subject><subject>Animals</subject><subject>Guanosine - analogs & derivatives</subject><subject>Guanosine - pharmacology</subject><subject>Guinea Pigs</subject><subject>Heart - drug effects</subject><subject>In Vitro Techniques</subject><subject>Invertebrates - metabolism</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscles - metabolism</subject><subject>Purine Nucleosides - antagonists & inhibitors</subject><subject>Purine Nucleosides - pharmacology</subject><subject>Receptors, Drug - drug effects</subject><subject>Receptors, Purinergic</subject><subject>Theophylline - pharmacology</subject><issn>0306-4492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhH0AlVJ4A5B8QnAI2E7sOhckVJUfqRKX3i1nsy5GSVzsBKlvT0orjpxGmpnd1X6EXHF2zxlXDyxnKiuKUtxqcVcypmUmT8j0zz4j5yl9MsZLnesJmSguNC_YlPilcwh9osHRFFqkne2HaJtmlwWAIUbfbeh2GAVp9FVIvsax3B29uPFAIwJu-xAT9R0FG2tvgdqupqkNof-g7ZCgwQty6myT8PKoM7J-Xq4Xr9nq_eVt8bTKIJfzPuM5CEAli7lWopKqckppWUqBkte5Ba61zhWWICtghSphbAlE55gDxot8Rm4Oa7cxfA2YetP6BNg0tsMwJDMvci6FFmOxOBQhhpQiOrONvrVxZzgze6hmT8_s6RktzC9UI8ex6-P-oWqx_hs6Eh3zx0OO44_fHqNJ4LEDrP3IqTd18P8f-AF-SYm7</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Fuhrman, Frederick A.</creator><creator>Fuhrman, Geraldine J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle</title><author>Fuhrman, Frederick A. ; Fuhrman, Geraldine J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-13c2ce6547862b56bf6685952e51d3ac188836e9c5bc0469c62b2eeff0fc0143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adenosine - analogs & derivatives</topic><topic>Adenosine - pharmacology</topic><topic>Animals</topic><topic>Guanosine - analogs & derivatives</topic><topic>Guanosine - pharmacology</topic><topic>Guinea Pigs</topic><topic>Heart - drug effects</topic><topic>In Vitro Techniques</topic><topic>Invertebrates - metabolism</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscles - metabolism</topic><topic>Purine Nucleosides - antagonists & inhibitors</topic><topic>Purine Nucleosides - pharmacology</topic><topic>Receptors, Drug - drug effects</topic><topic>Receptors, Purinergic</topic><topic>Theophylline - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuhrman, Frederick A.</creatorcontrib><creatorcontrib>Fuhrman, Geraldine J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. C, Comparative pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuhrman, Frederick A.</au><au>Fuhrman, Geraldine J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle</atitle><jtitle>Comparative biochemistry and physiology. C, Comparative pharmacology</jtitle><addtitle>Comp Biochem Physiol C</addtitle><date>1982</date><risdate>1982</risdate><volume>72</volume><issue>2</issue><spage>203</spage><epage>210</epage><pages>203-210</pages><issn>0306-4492</issn><abstract>1. Certain marine sponges and dorid nudibranchs contain adenosine, 2-methoxyadenosine, 2′-deoxyadenosine, isoguanosine and 1-methylisoguanosine as free ribosbides.
2. These ribosides have negative inotropic and chronotropic activity on the isolated guinea-pig atria. The decreasing order of activity is isoguanosine > 1-methylisoguanosine > adenosine > 2-methyoxyadenosine > 2′-deoxyadenosine.
3. Adenosine and 1-methylisoguanosine inhibit the spontaneous contractions of the rabbit ileum and this effect is antagonized by theophylline.
4. All these naturally-occurring purine ribosides appear to act on the same purinergic receptors in the atria, since log concentration-response curves are parallel.
5. Theophylline is a competitive antagonist of adenosine, isoguanosine and 1-methylisoguanosine on the guinea-pig atria.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>6128140</pmid><doi>10.1016/0306-4492(82)90085-5</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0306-4492 |
| ispartof | Comparative biochemistry and physiology. C, Comparative pharmacology, 1982, Vol.72 (2), p.203-210 |
| issn | 0306-4492 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine - analogs & derivatives Adenosine - pharmacology Animals Guanosine - analogs & derivatives Guanosine - pharmacology Guinea Pigs Heart - drug effects In Vitro Techniques Invertebrates - metabolism Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscles - metabolism Purine Nucleosides - antagonists & inhibitors Purine Nucleosides - pharmacology Receptors, Drug - drug effects Receptors, Purinergic Theophylline - pharmacology |
| title | Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscle |
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