Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus. Here we show that the transcriptional coactivator PGC-1 is stron...

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Veröffentlicht in:	Nature (London) 2001-09, Vol.413 (6852), p.131-138
Hauptverfasser:	Spiegelman, Bruce M, Yoon, J. Cliff, Puigserver, Pere, Chen, Guoxun, Donovan, Jerry, Wu, Zhidan, Rhee, James, Adelmant, Guillaume, Stafford, John, Kahn, C. Ronald, Granner, Daryl K, Newgard, Christopher B
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Motifs Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Biological and medical sciences Blood Blood Glucose - metabolism Cell Line Cyclic AMP - metabolism Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism DNA-Binding Proteins Fasting Fundamental and applied biological sciences. Psychology Gluconeogenesis Glucose hepatic nuclear factor-4^a Hepatocyte Nuclear Factor 4 Hormones - metabolism Insulin Insulin - physiology Lipids. Glycolipids Liver Liver - metabolism Male Metabolisms and neurohumoral controls Mice Mice, Knockout Obesity - genetics Obesity - metabolism PGC-1 protein Phosphoenolpyruvate Carboxykinase (GTP) - genetics Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Phosphoproteins - metabolism Rats Rats, Wistar Receptor, Insulin - genetics Receptor, Insulin - metabolism Receptors, Glucocorticoid - metabolism Response Elements RNA, Messenger - metabolism Rodents Tissues Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Tumor Cells, Cultured Vertebrates: anatomy and physiology, studies on body, several organs or systems
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