Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects

Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation, ΔF508, results in the production of a misfolded CFTR protein that is retained in the endoplasmic reticulum and targeted for degradation. Curcumin is a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-04, Vol.304 (5670), p.600-602
Hauptverfasser:	Egan, Marie E., Pearson, Marilyn, Weiner, Scott A., Rajendran, Vanathy, Rubin, Daniel, Glöckner-Pagel, Judith, Canny, Susan, Du, Kai, Lukacs, Gergely L., Caplan, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Attrition (Research Studies) Biological and medical sciences Body Weight Calcium - metabolism Calnexin - metabolism Care and treatment Cell Line Cell lines Cell Membrane - metabolism CHO cells Circles Clinical trials Cricetinae Cumin Curcumin Curcumin - administration & dosage Curcumin - pharmacology Curcumin - therapeutic use Cystic fibrosis Cystic Fibrosis - drug therapy Cystic Fibrosis - genetics Cystic Fibrosis - physiopathology Cystic Fibrosis Transmembrane Conductance Regulator - chemistry Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Electrolytes - pharmacology Endoplasmic Reticulum - metabolism Gene Targeting General pharmacology Genes Glycosylation Health aspects Humans Intestinal Mucosa - drug effects Intestinal Mucosa - physiology Intestinal Obstruction - prevention & control Iodides Isoproterenol - pharmacology Knockout mice Medical sciences Medical treatment Membrane Potentials - drug effects Mice Mice, Knockout Mutation Nasal Mucosa - drug effects Nasal Mucosa - physiology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Polyethylene Glycols - pharmacology Protein Folding Proteins Pumps Quality Control Rectum Transfection Turmeric
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