Cunninghamella – A microbial model for drug metabolism studies – A review
Drug metabolism studies constitute an important and necessary step in the evaluation of drug efficacy and safety. In vivo drug metabolism studies suffer from many disadvantages. Hence there is a rise in validation of in vitro microbial models. This review describes the transformation studies of drug...
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| Veröffentlicht in: | Biotechnology advances 2009-01, Vol.27 (1), p.16-29 |
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| container_title | Biotechnology advances |
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| creator | Asha, Sepuri Vidyavathi, Maravajhala |
| description | Drug metabolism studies constitute an important and necessary step in the evaluation of drug efficacy and safety.
In vivo drug metabolism studies suffer from many disadvantages. Hence there is a rise in validation of
in vitro microbial models. This review describes the transformation studies of drugs by the fungus,
Cunninghamella and correlating them with the metabolism/biotransformation in animal systems and providing technical methods to develop microbial models. Emphasis is laid on the potential of
Cunninghamella fungus to mimic mammalian drug biotransformations and to use as
in vitro model for drug metabolism studies and for further toxicological and pharmacological studies of metabolites. |
| doi_str_mv | 10.1016/j.biotechadv.2008.07.005 |
| format | Article |
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In vivo drug metabolism studies suffer from many disadvantages. Hence there is a rise in validation of
in vitro microbial models. This review describes the transformation studies of drugs by the fungus,
Cunninghamella and correlating them with the metabolism/biotransformation in animal systems and providing technical methods to develop microbial models. Emphasis is laid on the potential of
Cunninghamella fungus to mimic mammalian drug biotransformations and to use as
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In vivo drug metabolism studies suffer from many disadvantages. Hence there is a rise in validation of
in vitro microbial models. This review describes the transformation studies of drugs by the fungus,
Cunninghamella and correlating them with the metabolism/biotransformation in animal systems and providing technical methods to develop microbial models. Emphasis is laid on the potential of
Cunninghamella fungus to mimic mammalian drug biotransformations and to use as
in vitro model for drug metabolism studies and for further toxicological and pharmacological studies of metabolites.</description><subject>Animals</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Biotransformation</subject><subject>Cunninghamella</subject><subject>Cunninghamella - enzymology</subject><subject>Cunninghamella - metabolism</subject><subject>CYP450</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Drug</subject><subject>Eukaryotic Cells - enzymology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>In vitro metabolism study</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Methods. Procedures. 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in vitro microbial models. This review describes the transformation studies of drugs by the fungus,
Cunninghamella and correlating them with the metabolism/biotransformation in animal systems and providing technical methods to develop microbial models. Emphasis is laid on the potential of
Cunninghamella fungus to mimic mammalian drug biotransformations and to use as
in vitro model for drug metabolism studies and for further toxicological and pharmacological studies of metabolites.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>18775773</pmid><doi>10.1016/j.biotechadv.2008.07.005</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0734-9750 |
| ispartof | Biotechnology advances, 2009-01, Vol.27 (1), p.16-29 |
| issn | 0734-9750 1873-1899 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Cunninghamella Cunninghamella - enzymology Cunninghamella - metabolism CYP450 Cytochrome P-450 Enzyme System - metabolism Drug Eukaryotic Cells - enzymology Fundamental and applied biological sciences. Psychology Humans In vitro metabolism study Metabolism Metabolites Methods. Procedures. Technologies Microbial metabolites Microbial model Models, Biological Pharmaceutical Preparations - metabolism |
| title | Cunninghamella – A microbial model for drug metabolism studies – A review |
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