Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient Mice

Plasticity of mature hippocampal CA1 synapses is dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-t...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-06, Vol.292 (5526), p.2501-2504
Hauptverfasser:	Mack, Volker, Burnashev, Nail, Katharina M. M. Kaiser, Rozov, Andrei, Jensen, Vidar, Hvalby, Øvind, Seeburg, Peter H., Sakmann, Bert, Sprengel, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging AMPA receptors Animals Behavioral neuroscience Biological and medical sciences Cells Central nervous system Dendrites - metabolism Doxycycline - pharmacology Electric Stimulation Electrophysiology Excitatory Postsynaptic Potentials Fluorescence Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins Hippocampus (Brain) Hippocampus - metabolism Hippocampus - physiology Lesions Long term potentiation Luminescent Proteins Mice Mice, Transgenic Neuronal Plasticity Neurons Neuroplasticity Patch-Clamp Techniques Proteins Pyramidal cells Pyramidal Cells - metabolism Pyramidal Cells - physiology Receptors Receptors, AMPA - genetics Receptors, AMPA - metabolism Recombinant Fusion Proteins - metabolism Rodents Statistical Significance Synapses Synapses - metabolism Synapses - physiology Transgenes Vertebrates: nervous system and sense organs
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