Rapid Attenuation of Response to Nifedipine in Primary Pulmonary Hypertension
In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reductio...
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| Veröffentlicht in: | Chest 1982-12, Vol.82 (6), p.793-794 |
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| container_end_page | 794 |
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| container_issue | 6 |
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| container_title | Chest |
| container_volume | 82 |
| creator | Wood, Bruce A. Tortoledo, Francisco Luck, Jerry C. Fennell, William H. |
| description | In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reduction in systemic vascular resistance, the initial drug-related reduction in pulmonary vascular resistance was progressively attenuated with the subsequent four doses of nifedipine, 20 mg. |
| doi_str_mv | 10.1378/chest.82.6.793 |
| format | Article |
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While there was a persistent reduction in systemic vascular resistance, the initial drug-related reduction in pulmonary vascular resistance was progressively attenuated with the subsequent four doses of nifedipine, 20 mg.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.82.6.793</identifier><identifier>PMID: 7140411</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Female ; Humans ; Hypertension, Pulmonary - drug therapy ; Nifedipine - administration & dosage ; Nifedipine - pharmacology ; Nifedipine - therapeutic use ; Pyridines - therapeutic use ; Vascular Resistance - drug effects</subject><ispartof>Chest, 1982-12, Vol.82 (6), p.793-794</ispartof><rights>1982 The American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-921c17eb7fa4868714c929d2b61fca59da241282f00ba2d78508ce972594d9e13</citedby><cites>FETCH-LOGICAL-c378t-921c17eb7fa4868714c929d2b61fca59da241282f00ba2d78508ce972594d9e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7140411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, Bruce A.</creatorcontrib><creatorcontrib>Tortoledo, Francisco</creatorcontrib><creatorcontrib>Luck, Jerry C.</creatorcontrib><creatorcontrib>Fennell, William H.</creatorcontrib><title>Rapid Attenuation of Response to Nifedipine in Primary Pulmonary Hypertension</title><title>Chest</title><addtitle>Chest</addtitle><description>In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reduction in systemic vascular resistance, the initial drug-related reduction in pulmonary vascular resistance was progressively attenuated with the subsequent four doses of nifedipine, 20 mg.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - drug therapy</subject><subject>Nifedipine - administration & dosage</subject><subject>Nifedipine - pharmacology</subject><subject>Nifedipine - therapeutic use</subject><subject>Pyridines - therapeutic use</subject><subject>Vascular Resistance - drug effects</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAYRS0EgvJY2ZAysSX4kSb2WCFeUnkIwWy5zhfqKrGDnYD673FJBSxMtqV7j64PQqcEZ4SV_EIvIfQZp1mRlYLtoAkRjKRsmrNdNMGY0JQVgh6gwxBWOL6JKPbRfklynBMyQffPqjNVMut7sIPqjbOJq5NnCJ2zAZLeJQ-mhsp0xkJibPLkTav8OnkamtbZze123YGP7RC7x2ivVk2Ak-15hF6vr14ub9P5483d5Wye6ji5TwUlmpSwKGuV84LHMVpQUdFFQWqtpqJSNCeU0xrjhaJVyaeYaxAlnYq8EkDYETofuZ1370MUIFsTNDSNsuCGIMucEZZzHoPZGNTeheChlt34AUmw3PiT3_4kp7KQ0V8snG3Jw6KF6ie-FfYLXJq35afxIEOrmiam2YhaucFb1fwB8rEA0ceHAS-DNmB1dOpB97Jy5r8tX-4skNU</recordid><startdate>198212</startdate><enddate>198212</enddate><creator>Wood, Bruce A.</creator><creator>Tortoledo, Francisco</creator><creator>Luck, Jerry C.</creator><creator>Fennell, William H.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198212</creationdate><title>Rapid Attenuation of Response to Nifedipine in Primary Pulmonary Hypertension</title><author>Wood, Bruce A. ; Tortoledo, Francisco ; Luck, Jerry C. ; Fennell, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-921c17eb7fa4868714c929d2b61fca59da241282f00ba2d78508ce972594d9e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - drug therapy</topic><topic>Nifedipine - administration & dosage</topic><topic>Nifedipine - pharmacology</topic><topic>Nifedipine - therapeutic use</topic><topic>Pyridines - therapeutic use</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Bruce A.</creatorcontrib><creatorcontrib>Tortoledo, Francisco</creatorcontrib><creatorcontrib>Luck, Jerry C.</creatorcontrib><creatorcontrib>Fennell, William H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Bruce A.</au><au>Tortoledo, Francisco</au><au>Luck, Jerry C.</au><au>Fennell, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid Attenuation of Response to Nifedipine in Primary Pulmonary Hypertension</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1982-12</date><risdate>1982</risdate><volume>82</volume><issue>6</issue><spage>793</spage><epage>794</epage><pages>793-794</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reduction in systemic vascular resistance, the initial drug-related reduction in pulmonary vascular resistance was progressively attenuated with the subsequent four doses of nifedipine, 20 mg.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7140411</pmid><doi>10.1378/chest.82.6.793</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1982-12, Vol.82 (6), p.793-794 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74313488 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Female Humans Hypertension, Pulmonary - drug therapy Nifedipine - administration & dosage Nifedipine - pharmacology Nifedipine - therapeutic use Pyridines - therapeutic use Vascular Resistance - drug effects |
| title | Rapid Attenuation of Response to Nifedipine in Primary Pulmonary Hypertension |
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